The effect of respiratoty function with wrapping elasticated collagen sheets in rats COPD model

• Project/Area Number: 21791319
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Gifu University
• Principal Investigator: SHIRAHASHI Koyo 岐阜大学, 医学部・附属病院, 助教 (40362149)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肺気腫 / 胸部外科

Research Abstract

To improve lung compliance and to maintain airflow, we evaluated the effect of respiratoty function with wrapping elasticated collagen sheets in rats COPD model. When heated to 100℃, the FIBRIGEL was shrank to 66% of their original diameter and the weak-elasticated collagen sheet was formed. Ex vivo, airflow and tidal volume were increased with decreasing the size of wrapping sheet. Airway pressure and airflow were increased with increasing the number of sheet. In vivo, there were no changes in air pressure, airflow and tidal volume using wrapping sheet. Assessment of time course in respiratory functional changes and pathological evaluation were not completed.