Development of the molecular target therapy for the cytokine receptor for suppression of rejection after the lung transplantation
| Project/Area Number |
21791323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 呼吸器外科学 / Th17 / 肺移植 / 拒絶 / 閉塞性細気管支炎 / Treg / リンパ球分化誘導 / 制御性T細胞regulatory T cell / 慢性拒絶(chronic rejection) / 閉塞性細気管支炎(bronchiolitis obliterans:BO) / regulatory T cell / rejection / bronchiolitis obliterans |
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| Research Abstract |
IL-6 production increased in local area, but not in peripheral, in allografts of the mouse BO model, and IL-17 production also locally increased without an alteration in the proportion of peripheral Th17 cells while the level of peripheral Treg decrease d. In addition, IL-6 blocking may suppress BO formation.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Lung function early after lung transplantation is correlated with the frequency of regulatory T cells2012
Author(s)
Nakagiri T, Warnecke G, Avsar M, Thissen S, Kruse B, Kuhn C, Ziehme P, Knofel AK, Madrahimov N, Okumura M, Sawa Y, Gottlieb J, Simon AR, Haverich A, Struber M
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Journal Title
Surg Today
Volume: 42(3)
Pages: 250-8
NAID
Related Report
Peer Reviewed
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