Development of the molecular target therapy for the cytokine receptor for suppression of rejection after the lung transplantation

• Project/Area Number: 21791323
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: TOMOYUKI Nakagiri 大阪大学, 医学系・研究科, 助教 (70528710)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 呼吸器外科学 / Th17 / 肺移植 / 拒絶 / 閉塞性細気管支炎 / Treg / リンパ球分化誘導 / 制御性T細胞regulatory T cell / 慢性拒絶(chronic rejection) / 閉塞性細気管支炎(bronchiolitis obliterans:BO) / regulatory T cell / rejection / bronchiolitis obliterans

Research Abstract

IL-6 production increased in local area, but not in peripheral, in allografts of the mouse BO model, and IL-17 production also locally increased without an alteration in the proportion of peripheral Th17 cells while the level of peripheral Treg decrease d. In addition, IL-6 blocking may suppress BO formation.

Research Products

• [Journal Article] Mini Review Transplantation Immunology The Basics of Thl7 and Interleukin-6 in Transplantation. (2012)
  • Author(s): Nakagiri T, Inoue M, Minami M, Shintani Y, Okumura M
  • Journal Title: Transplant Proc Volume: 44(4) Pages: 1035-40
  • Peer Reviewed
• [Journal Article] Lung function early after lung transplantation is correlated with the frequency of regulatory T cells (2012)
  • Author(s): Nakagiri T, Warnecke G, Avsar M, Thissen S, Kruse B, Kuhn C, Ziehme P, Knofel AK, Madrahimov N, Okumura M, Sawa Y, Gottlieb J, Simon AR, Haverich A, Struber M
  • Journal Title: Surg Today Volume: 42(3) Pages: 250-8
  • NAID: 10030231190
  • Peer Reviewed
• [Journal Article] Lung function early after lung transplantation is correlated with the frequency of regulatory T cells (2012)
  • Author(s): Nakagiri T
  • Journal Title: Surgery Today Volume: 42 Issue: 3 Pages: 250-8
  • DOI: 10.1007/s00595-011-0087-3
  • NAID: 10030231190
  • Peer Reviewed
• [Journal Article] Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of Bronchiolitis obliterans (2010)
  • Author(s): Nakagiri T, Inoue M, Morii E, Minami M, Sawabata N, Utsumi T, Kadota Y, Ideguchi K, Tokunaga T, Okumura M
  • Journal Title: Transplantation Volume: 89(11) Pages: 1312-9
  • Peer Reviewed
• [Journal Article] Local IL-17 Production and a Decrease in Peripheral Blood Regulatory T cells in an Animal Model of Bronchiolitis Obliterans (2010)
  • Author(s): Nakagiri T, Inoue M, Morii E, Minami M, Sawabata N, Utsumi T, Kadota Y, Ideguchi K, Tokunaga T, Okumura M
  • Journal Title: Transplantation Volume: 89 Pages: 1312-1319
  • Peer Reviewed
• [Journal Article] Local IL-17 Production and a Decrease in Peripheral Blood Regulatory T cells in an Animal Model of Bronchiolitis Obliterans
  • Author(s): Nakagiri T
  • Journal Title: Transplantation (In press)
  • Peer Reviewed
• [Presentation] BOに対するTh17およびIL-6を中心とした移植免疫 (2012)
  • Author(s): 中桐伴行
  • Organizer: 第28回日本肺および心肺移植研究会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-28
• [Presentation] 異系移植拒絶におけるIL-6増幅回路の役割 (2012)
  • Author(s): 中桐伴行
  • Organizer: 第28回日本肺および心肺移植研究会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-28
• [Presentation] IL-6 and TH17 in Transplantation (2011)
  • Author(s): Nakagiri T
  • Organizer: Congress of the Asian Society of Transplantation 2011
  • Place of Presentation: Soeul
  • Year and Date: 2011-09-25
• [Presentation] IL-6 and TH17 in Transplantation (2011)
  • Author(s): Nakagiri T
  • Organizer: CAST2011
  • Place of Presentation: Souel, Korea(招待講演)
  • Year and Date: 2011-09-25
• [Presentation] ブタを用いたDonor肺・心肺摘出シミュレーションの紹介 (2011)
  • Author(s): 中桐伴行、井上匡美、南正人、新谷康、門田嘉久、澤端章好、奥村明之進
  • Organizer: 日本肺および心肺移植研究会
  • Place of Presentation: 岡山
  • Year and Date: 2011-01-29
• [Presentation] 制御性T細胞の割合と肺移植後早期の呼吸機能は相関する (2010)
  • Author(s): 中桐伴行, Warnecke G, Haverich A, Stuber M, 井上匡美、南正人、澤端章好、奥村明之進
  • Organizer: 第26回肺および心肺移植研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-08
• [Presentation] Analysis of the regulatory T-cell and Th17 subsets in peripheral blood 1 ymphocytes and local accumulation of Th17 in patients with acute rejection after pulmonary transplantation (2009)
  • Author(s): Nakagiri T
  • Organizer: Lung Transplantation Conference (5)
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-13
• [Presentation] Th17リンパ球の肺移植後拒絶反応への関与-マウス異所性気管移植モデルを用いた検討- (2009)
  • Author(s): 中桐伴行
  • Organizer: 日本呼吸器外科学会総会(26)
  • Place of Presentation: 小倉
  • Year and Date: 2009-05-15
• [Presentation] Th17 Lymphocyte Proprotion Increased in Animal Model of Bronchiolitis Obliterans after Lung Transplantation (2009)
  • Author(s): Nakagiri T
  • Organizer: The International Society for Heart & Lung Transplantation (29)
  • Place of Presentation: Paris, FRANCE
  • Year and Date: 2009-04-23