| Project/Area Number |
21791341
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SAITO Ryuta Tohoku University, 大学院・医学系研究科, 助教 (10400243)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 脳腫瘍 / 化学療法 / 免疫療法 / ドラッグデリバリー / 免疫遺伝子治療 / Convection-enhanced delivery / 免疫 / ACNU / OX-40 ligand / 脳血液関門 / 遺伝子治療 / convection-enhanced delivery / OX40 ligand |
|---|
| Research Abstract |
This study was started with the aim to develop systemic immunity by locally delivering agents with novel drug delivery system, i.e. convection-enhanced delivery. First, we analyzed the changes in brain tissue that received CED of chemotherapeutic agent ; ACNU. Transient opening of the Blood-brain barrier was noted with the delivery of ACNU at safety dose. With this finding, we tried to combine systemic chemotherapy using liposomal doxorubicin with CED of ACNU to treat rodent brain tumor model. Prolonged survival of the model was noted with this treatment. Consequently, we tested the ability of local CED delivery of adenovirus encoding OX-40 protein to induce systemic immunity. With this strategy antitumor efficacy was observed using rodent brain tumor model.
|
