Basic research of photodynamic therapy for the malignant glioma using a newly photosensitizer.

• Project/Area Number: 21791346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Gunma University
• Principal Investigator: SUGAWARA Kenichi Gunma University, 医学部, 助教 (50375573)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 悪性神経膠腫 / 光線力学療法 / ポルフィリン誘導体

Research Abstract

Various photosensitizers are used in a photodynamic therapy for human malignant gliomas. However, no satisfactory results are obtained because of low cytotoxicities. We experimented using a porphyrin derivative by silylation, which increased production efficiency of singlet oxygen with cytotoxicity compared with other photosensitizers. Photodynamic therapy of human malignant gliomas using this newly photosensitizer may be possible.