|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Various photosensitizers are used in a photodynamic therapy for human malignant gliomas. However, no satisfactory results are obtained because of low cytotoxicities. We experimented using a porphyrin derivative by silylation, which increased production efficiency of singlet oxygen with cytotoxicity compared with other photosensitizers. Photodynamic therapy of human malignant gliomas using this newly photosensitizer may be possible.