Identification of the mechanism of self-proliferation in brain tumor stem cells

Research Project

Project/Area Number	21791369
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Kyushu University
Principal Investigator	MATSUMOTO KENICHI Kyushu University, 医学研究院, 研究員 (80423581)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	脳腫瘍学 / 脳腫瘍幹細胞 / 非対称分裂
Research Abstract	To dissect the biological mechanism of the self-proliferation in glioma stem cell, we first tried to establish the glioma cell lines with stem cell activity. We removed the glioma tissues from the patients and performed primary culture of these cells with EGF and EGF in serum free conditon. So far, we have established four cell lines which continue to proliferate more than 10 passages. Since we have not proved the stem cell potential of these cells, the mechanism of the self-proliferation have not been identified.

Report

(3 results)