| Project/Area Number |
21791401
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
IKEUCHI Masahiko Kochi University, 教育研究部医療学系, 講師 (00372730)
|
|---|
| Research Collaborator |
KATHLEEN Sluka アイオワ大学, 理学療法科, 教授
IZUMI Masashi 高知大学, 大学院
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 変形性関節症 / 関節痛 / 酸感受性イオンチャネル / 酸 / 痛覚過敏 |
|---|
| Research Abstract |
The mechanism of osteoarthritic pain is largely unknown. Nociceptors are excited by acidity through acid sensing ion channels. We examined the possibility that synovial fluid acidity might play a role in osteoarthritic pain. Our results showed that acid sensing ion channels are essential for producing widespread pain in osteoarthritis.
|
