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Role of synovial fluid acidity and acid sensing ion channel in osteoarthritic pain

Research Project

Project/Area Number 21791401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKochi University

Principal Investigator

IKEUCHI Masahiko  Kochi University, 教育研究部医療学系, 講師 (00372730)

Research Collaborator KATHLEEN Sluka  アイオワ大学, 理学療法科, 教授
IZUMI Masashi  高知大学, 大学院
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords変形性関節症 / 関節痛 / 酸感受性イオンチャネル / 酸 / 痛覚過敏
Research Abstract

The mechanism of osteoarthritic pain is largely unknown. Nociceptors are excited by acidity through acid sensing ion channels. We examined the possibility that synovial fluid acidity might play a role in osteoarthritic pain. Our results showed that acid sensing ion channels are essential for producing widespread pain in osteoarthritis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] 変形性関節症モデルにおける酸感受性イオンチャネル(ASIC3)の発現変化2010

    • Author(s)
      泉仁、池内昌彦、陳乃峰、谷俊一
    • Journal Title

      日本整形外科学会雑誌 84巻

      Pages: 1295-1295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 変形性膝関節症モデルにおける酸感受性イオンチャネル(ASIC3)の発現変化2010

    • Author(s)
      泉仁、池内昌彦, ほか
    • Journal Title

      日本整形外科学会雑誌

      Volume: 84 Pages: 1265-1265

    • Related Report
      2010 Annual Research Report
  • [Presentation] Intraarticular hyaluronan injection changes ASIC3 expression in dorsal root ganglia in a rat model of osteoarthritis2011

    • Author(s)
      泉仁、池内昌彦、陳乃峰、谷俊一
    • Organizer
      2011 annual meeting of the orthopaedic research society
    • Place of Presentation
      アメリカ・ロングビーチ
    • Year and Date
      2011-01-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Intraarticular hyaluronan injection changes ASIC3 expression in dorsal root ganglia in a rat model of osteoarthritis2011

    • Author(s)
      泉仁、池内昌彦, ほか
    • Organizer
      2011 annual meeting of the orthopaedic research society
    • Place of Presentation
      Long Beach Convention Center(アメリカ・ロングビーチ)
    • Year and Date
      2011-01-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 変形性関節症における関節痛~臨床像と病態に関する検討~2010

    • Author(s)
      池内昌彦
    • Organizer
      第3回日本運動器疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 変形性関節症における関節痛~臨床像と病態に関する検討~2010

    • Author(s)
      池内昌彦
    • Organizer
      第3回日本運動器疼痛学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ASIC3 upregulation in a rat model of osteoarthritis2010

    • Author(s)
      泉仁、池内昌彦、陳乃峰、谷俊一
    • Organizer
      IASP 13^th world congress of pain
    • Place of Presentation
      カナダ・モントリオール
    • Year and Date
      2010-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] ASIC3 upregulation in a rat model of osteoarthritis2010

    • Author(s)
      泉仁、池内昌彦, ほか
    • Organizer
      IASP 13^<th> world congress of pain
    • Place of Presentation
      Palais des Congres de Montreal(カナダ・モントリオール)
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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