Role of synovial fluid acidity and acid sensing ion channel in osteoarthritic pain
| Project/Area Number |
21791401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kochi University |
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Principal Investigator |
IKEUCHI Masahiko Kochi University, 教育研究部医療学系, 講師 (00372730)
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| Research Collaborator |
KATHLEEN Sluka アイオワ大学, 理学療法科, 教授
IZUMI Masashi 高知大学, 大学院
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 変形性関節症 / 関節痛 / 酸感受性イオンチャネル / 酸 / 痛覚過敏 |
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| Research Abstract |
The mechanism of osteoarthritic pain is largely unknown. Nociceptors are excited by acidity through acid sensing ion channels. We examined the possibility that synovial fluid acidity might play a role in osteoarthritic pain. Our results showed that acid sensing ion channels are essential for producing widespread pain in osteoarthritis.
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Report
(3 results)
Research Products
(8 results)
