The effect of tumor secreting physiologically active substances for synaptic transmission.

Research Project

Project/Area Number	21791458
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Miyazaki
Principal Investigator	KASHIWADA Masatoshi University of Miyazaki, 医学部, 助教 (20336316)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000) Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords	リドカイン / アポトーシス / 腫瘍特異性 / 水棲カタツムリ / exocytosis / NGF / EPSP / MEPPs
Research Abstract	Many studies have indicated that the expression of for NaV1.3 a kind of voltage-dependent sodium channels by tumor secreting physiologically active substances is one of the mechanisms of cancer pain. The aim of this study was to invest the effect of tumor secreting physiologically active substances for expression of voltage-dependent sodium channels by using Rat dorsal root ganglion (DRG) neurons. Results : NaV 1.3 was most expressed by NGF and TNF-α. Conclusion : NaV1.3 expression by tumor secreting physiologically active substances such as NGF and TNF-α may be one of the causes of cancer pain.

Report

(3 results)