The effect of tumor secreting physiologically active substances for synaptic transmission.
| Project/Area Number |
21791458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KASHIWADA Masatoshi University of Miyazaki, 医学部, 助教 (20336316)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | リドカイン / アポトーシス / 腫瘍特異性 / 水棲カタツムリ / exocytosis / NGF / EPSP / MEPPs |
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| Research Abstract |
Many studies have indicated that the expression of for NaV1.3 a kind of voltage-dependent sodium channels by tumor secreting physiologically active substances is one of the mechanisms of cancer pain. The aim of this study was to invest the effect of tumor secreting physiologically active substances for expression of voltage-dependent sodium channels by using Rat dorsal root ganglion (DRG) neurons. Results : NaV 1.3 was most expressed by NGF and TNF-α. Conclusion : NaV1.3 expression by tumor secreting physiologically active substances such as NGF and TNF-α may be one of the causes of cancer pain.
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Report
(3 results)
Research Products
(3 results)
