Gene-expression analysis of AR-negative prostate cancer cells
| Project/Area Number |
21791508
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
TAMURA Kenji Kochi University, 教育研究部医療学系, 助教 (50464384)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | マイクロアレイ / ゲノム / トランスレーショナルリサーチ / 癌 / 発現制御 |
|---|
| Research Abstract |
To identify prostate cancer (PC) specific biomarkers, which are independent of PSA, we analyzed gene expression profiles of PC cell lines (PC-3, DU145, 22Rv1 and LNCaP) by genome-wide cDNA microarray and found dozens of trans-activated genes in AR-negative PC cell lines (PC-3 and DU145), compared with AR-positive PC cell lines (22Rv1 and LNCaP). Among them, we identified a new biomarker, KURO3, as an overexpressed gene in PC-3 cell line and clinical high-grade prostate cancers.
|
Report
(3 results)
Research Products
(3 results)
