Pericyte coverage of differentiated microvessels in clear cell renal cell carcinoma correlates with poorer prognosis
| Project/Area Number |
21791526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 淡明腎細胞癌 / 血管周皮細胞 / 血管内皮細胞 / 腎細胞癌 |
|---|
| Research Abstract |
Purpose : The clinical significance of vascular maturation, which is marked by the presence of the pericytes, is still unclear. In the present study, we evaluated the correlation between vascular maturation and patients' prognosis in CCRCC.
Experimental Design : We analyzed formalin-fixed, paraffin-embedded tissue sections from 162 primary and 20 metastatic CCRCC patients. The sections were double-stained with pericyte marker anti-SMA antibody as an indicator of vascular maturation and the differentiated blood vessel marker anti-CD34 antibody. The Nuance Multispectral Imaging System was used to quantify those two cell types. We investigated the relationship between pericyte coverage(PC) and the clinicopathological parameters such as tumor grades, metastasis status, and patient survival.
Results : Lower PC were significantly correlated with higher tumor grades and poorer patient's prognosis. Lower PC was also significantly correlated with metastasis. More matured differentiated blood vessels seem to indicate better prognosis. The present study suggested that vascular maturation in CCRCC was important.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma2010
Author(s)
Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem-Ouazana D, Debre B, Flam T, Thiounn N, Zerbib M, Benoit G, Droupy S, Molinie V, Vieillefond A, Tan PH, Richard S, Teh BT
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Journal Title
BMC Cancer
Volume: 10
Pages: 196-196
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Journal Title
Jpn J Radiol
Volume: 27(9)
Pages: 348-54
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Journal Title
CANCER LETTERS
Volume: 272/2
Pages: 260-7
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[Journal Article] Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response
Author(s)
Koeman JM, Russell RC, Tan MH, Petillo D, Westphal M, Koelzer K, Metcalf JL, Zhang Z, Matsuda D, Dykema KJ, Houseman HL, Kort EJ, Furge LL, Kahnoski RJ, Richard S, Vieillefond A, Swiatek PJ, Teh BT, Ohh M, Furge KA
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