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Pericyte coverage of differentiated microvessels in clear cell renal cell carcinoma correlates with poorer prognosis

Research Project

Project/Area Number 21791526
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

MATSUDA Daisuke  北里大学, 医学部, 助教 (50348570)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords淡明腎細胞癌 / 血管周皮細胞 / 血管内皮細胞 / 腎細胞癌
Research Abstract

Purpose : The clinical significance of vascular maturation, which is marked by the presence of the pericytes, is still unclear. In the present study, we evaluated the correlation between vascular maturation and patients' prognosis in CCRCC.
Experimental Design : We analyzed formalin-fixed, paraffin-embedded tissue sections from 162 primary and 20 metastatic CCRCC patients. The sections were double-stained with pericyte marker anti-SMA antibody as an indicator of vascular maturation and the differentiated blood vessel marker anti-CD34 antibody. The Nuance Multispectral Imaging System was used to quantify those two cell types. We investigated the relationship between pericyte coverage(PC) and the clinicopathological parameters such as tumor grades, metastasis status, and patient survival.
Results : Lower PC were significantly correlated with higher tumor grades and poorer patient's prognosis. Lower PC was also significantly correlated with metastasis. More matured differentiated blood vessels seem to indicate better prognosis. The present study suggested that vascular maturation in CCRCC was important.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma2011

    • Author(s)
      Min-Han Tan, Daisuke Matsuda, ほか24名
    • Journal Title

      BMC CANCER

      Volume: 10 Pages: 196-196

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma2010

    • Author(s)
      Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem-Ouazana D, Debre B, Flam T, Thiounn N, Zerbib M, Benoit G, Droupy S, Molinie V, Vieillefond A, Tan PH, Richard S, Teh BT
    • Journal Title

      BMC Cancer

      Volume: 10 Pages: 196-196

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cavernous hemangioma of the adrenal gland2009

    • Author(s)
      Matsuda, D., Iwamura, M., Baba, S
    • Journal Title

      Int J Urol

      Volume: 16 Pages: 424-424

    • NAID

      10025197669

    • Related Report
      2011 Final Research Report
  • [Journal Article] Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection2009

    • Author(s)
      Matsuda, D., Iwamura, M., Baba, S
    • Journal Title

      Int J Urol

      Volume: 16 Pages: 336-336

    • NAID

      10025197237

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cost comparison of curative therapies for localized prostate cancer in Japan : a single-institution experience2009

    • Author(s)
      Satoh T, Ishiyama H, Matsumoto K, Tabata K, Kitano M, Iwamura M, Kimura M, Minamida S, Yamashita H, Matsuda D, Kotani S, Niibe Y, Uemae M, Hayakawa K, Baba S
    • Journal Title

      Jpn J Radiol

      Volume: 27(9) Pages: 348-54

    • NAID

      50007373609

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cavernous hemangioma of the adrenal gland.2009

    • Author(s)
      Daisuke Matsuda, Masatsugu Iwamura
    • Journal Title

      INTERNATIONAL JOURNAL OF UROLOGY 16

      Pages: 424-424

    • NAID

      10025197669

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cost comparison of curative therapies for localized prostate cancer in Japan : a single-institution experience2009

    • Author(s)
      Takefumi Satoh, Daisuke Matsuda, et al
    • Journal Title

      Jpn J Radiol 27

      Pages: 348-354

    • NAID

      50007373609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection.2009

    • Author(s)
      Daisuke Matsuda, Masatsugu Iwamura
    • Journal Title

      INTERNATIONAL JOURNAL OF UROLOGY 16

      Pages: 336-336

    • NAID

      10025197237

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The French Kidney Cancer Study Group, Shiro Baba, Bin Tean The : Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC2008

    • Author(s)
      Daisuke Matsuda, Sok Kean Khoo, Aaron Massie, Masatsugu Iwamura, Jindong Chen, David Petillo, Bill Wondergem, Michael Avallone, Stephanie J. Kloostra, Min-Han Tan, Julie Koeman, Zhongfa Zhang, Richard J. Kahnoski
    • Journal Title

      CANCER LETTERS

      Volume: 272/2 Pages: 260-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] A comparison study reveals important features of agreement and disagreement between summarized DNA and RNA data obtained from renal cell carcinoma

    • Author(s)
      Zhang ZF, Matsuda D, Khoo SK, Buzzitta K, Block E, Petillo D, Richard S, Anema J, Furge KA, Teh BT
    • Journal Title

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

      Volume: 657/1 Pages: 77-83

    • Related Report
      2011 Final Research Report
  • [Journal Article] Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response

    • Author(s)
      Koeman JM, Russell RC, Tan MH, Petillo D, Westphal M, Koelzer K, Metcalf JL, Zhang Z, Matsuda D, Dykema KJ, Houseman HL, Kort EJ, Furge LL, Kahnoski RJ, Richard S, Vieillefond A, Swiatek PJ, Teh BT, Ohh M, Furge KA
    • Journal Title

      PloS GENETICS

      Volume: 9

    • Related Report
      2011 Final Research Report
  • [Presentation] グリセリン浣腸により溶血をきたした1例2011

    • Author(s)
      松田大介
    • Organizer
      第3回北里泌尿器科懇話会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎癌-現状と新しい治療の誕生-2010

    • Author(s)
      松田大介
    • Organizer
      第144回大和会公開医学講座
    • Place of Presentation
      東大和ケアセンター2F(東大和市)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「腎癌における診断・治療・手術及び珍しい症例のFREE DISCUSSION」:鏡視下手術における術前検査の重要性2010

    • Author(s)
      松田大介
    • Organizer
      第1回北里泌尿器科懇話会
    • Place of Presentation
      北里大学(相模原市)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] INFLUENCE OF BODY MASS INDEX IN LAPAROSCOPIC RADICAL NEPHRECTOMY : THE CORRELATION WITH PERIRENAL OR SUBCUTANEOUS FAT THICKNESS2010

    • Author(s)
      T Fujita, M Iwamura, H Tsumura, D Matsuda, ほか3名
    • Organizer
      Annual Meeting American Urological Association
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-05-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎細胞癌に対する腹腔鏡下根治的腎摘除術における長期予後の検討2010

    • Author(s)
      松田大介, ほか6名
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市民文化ホール・いわて県民情報交流センター、ホテルメトロポリタン盛岡本館/NEW WING・盛岡市アイスアリーナ(盛岡市)
    • Year and Date
      2010-04-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹腔鏡下腎部分切除術の技術的問題点と近未来像2010

    • Author(s)
      岩村正嗣、藤田哲夫、笹本治子、松田大介, ほか6名
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市民文化ホール・いわて県民情報交流センター、ホテルメトロポリタン盛岡本館/NEW WING・盛岡市アイスアリーナ(盛岡市)
    • Year and Date
      2010-04-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of copy number alteration in clear cell and papillary RCC2009

    • Author(s)
      松田大介
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      ホテルグランヴィア岡山(岡山)
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of copy number alteration in clear cell and papillary RCC2009

    • Author(s)
      松田大介, 岩村正嗣, 土田繭美, 木村将貴, 藤田哲夫, 佐藤威文, 馬場志郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Distribution of the positive surgical margin in laparoscopic prostatectomized specimens2008

    • Author(s)
      松田大介、岩村正嗣、佐藤威文、山田泰史、土田繭美、田畑健一、松本和将、馬場志郎
    • Organizer
      26th World Congress of Endourology & SWL
    • Place of Presentation
      上海
    • Year and Date
      2008-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 腹腔鏡下根治的前立腺摘除術における外科的切除縁陽性例と陽性部位の検討2008

    • Author(s)
      松田大介、岩村正嗣、土田繭美、佐藤威文、山田泰史、田畑健一、松本和将、馬場志郎
    • Organizer
      第22回日本Endourology and ESWL学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-11
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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