Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas.
Project/Area Number |
21791538
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 子宮頚癌 / 血管新生 / vasohibin / VEGF / 子宮頸癌 / 血管新生阻害物質 / 免疫染色 / 血管密度 / リンパ管密度 |
Research Abstract |
The aim of the present study is to clarify the critical roles of vasohibin in cervical carcinomas. We investigated the expression ratios of vasohibin and vascular endothelial growth factor (VEGF)receptor-2 on endothelium and microvessel density, lymphatic vessel density (LVD)by immunohistochemistry. Sixty-one squamous cell carcinoma (SCC), 18 mucinous adenocarcinoma (Adenocarcinoma), 38 carcinoma in situ (CIS), and 35 normal cervical epithelium were collected. This is the first study to elucidate the correlation between the expression of vasohibin in the stromal endothelial cells and the expression of VEGFR-2 in human cervical carcinomas.
|
Report
(4 results)
Research Products
(6 results)
-
[Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011
Author(s)
Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
-
Journal Title
Cancer Science
Volume: 102(2)
Pages: 446-451
NAID
Related Report
Peer Reviewed
-
-
-
-
-