| Project/Area Number |
21791541
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
HIRAKAWA Takashi Gunma Institute of Public Health and Environmental Sciences, 研究企画係, 研究員 (80375534)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | FSHレセプター / LHレセプター / ゴナドトロピン / 卵巣癌 |
|---|
| Research Abstract |
The expression of Gonadotrophin receptors mRNA and protein were confirmed in OSE-29 cells, derived from ovarian surface epithelial cells. The activation of ERK were observed in the presence of Gonadotrophins in dose-dependent manner. MEK inhibitor, U0126 inhibited the activation of ERK via Gonadotrophin receptor activation.
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