Pathophysiology of preeclampsia-the role of autophagy treated with cytokines

• Project/Area Number: 21791546
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: NAKASHIMA Akitoshi University of Toyama, 大学院・医学薬学研究部, 助教 (00436792)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生殖医学 / オートファジー / 妊娠 / 妊娠高血圧症候群 / サイトカイン / 可溶型エンドグリン / 妊娠免疫 / 妊娠高血圧候群 / 低酸素

Research Abstract

A decrease of extravillous trophoblast invasion was correlated with the inhibition of autophagy by soluble endoglin, which increases in serum in preeclamsia patients. This result could suggest the correlation between autophagy and pathophysiology of preeclampsia.

Research Products

• [Journal Article] Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases. (2011)
  • Author(s): Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S.Am.J
  • Journal Title: Reprod Immunol. 64 Pages: 4-11
  • Peer Reviewed
• [Journal Article] Circulating and decidual Th17 cell levels in healthy pregnancy. (2010)
  • Author(s): Nakashima A, Ito M, Yoneda S, Shiozaki A, Hidaka T, Saito S.Am.J
  • Journal Title: Reprod Immunol. 63 Pages: 104-109
  • Peer Reviewed
• [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour (2010)
  • Author(s): Ito M, Nakashima A, Hidaka T, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, Nikaido T, Saito S.J
  • Journal Title: Reprod Immunol. 84 Pages: 75-85
  • Peer Reviewed
• [Journal Article] Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy (2010)
  • Author(s): Saito S, Nakashima A, Shima T, Ito M.Am.J
  • Journal Title: Reprod Immunol. 84 Pages: 75-85
  • Peer Reviewed
• [Journal Article] Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer (2010)
  • Author(s): Takao H, Nakashima A, Shima T, Hasegawa T, Saito S.
  • Journal Title: Obstetrics and Gynecology International
  • Peer Reviewed
• [Journal Article] Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy. (2010)
  • Author(s): Nomoto K, Hori T, Kiya C, Fukuoka J, Nakashima A, Hidaka T, Saito S, Mikami Y, Tsuneyama K, Takano Y.
  • Journal Title: Pahology International. 60 Pages: 636-641
  • NAID: 10031123389
  • Peer Reviewed
• [Journal Article] Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases. (2010)
  • Author(s): Nakashima A, Ito M
  • Journal Title: American journal of reproductive immunology Volume: 64 Pages: 4-11
  • Peer Reviewed
• [Journal Article] Circulating and decidual Th17 cell levels in healthy pregnancy. (2010)
  • Author(s): Nakashima A, Ito M
  • Journal Title: American journal of reproductive immunology Volume: 63 Pages: 104-109
  • Peer Reviewed
• [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour (2010)
  • Author(s): Ito M, Nakashima A
  • Journal Title: Journal of reproductive immunology Volume: 84 Pages: 75-85
  • Peer Reviewed
• [Journal Article] Th1/Th2/Th17 and regulatory T cell paradigm in pregnancy. (2010)
  • Author(s): Saito S, Nakashima A
  • Journal Title: American journal of reproductive immunology Volume: 63 Pages: 601-610
  • Peer Reviewed
• [Journal Article] Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late prengnancy in allogeneic mice. (2010)
  • Author(s): Shima T, Sasaki Y, Nakashima A
  • Journal Title: Journal of reproductive immunology Volume: 85 Pages: 121-129
  • Peer Reviewed
• [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour (2010)
  • Author(s): Ito M, Nakashima A
  • Journal Title: Journal of reproductive immunology 84 Pages: 75-85
  • Peer Reviewed
• [Journal Article] Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases. (2010)
  • Author(s): Nakashima A, Ito M
  • Journal Title: American journal of reproductive immunology (in press)
  • Peer Reviewed
• [Journal Article] Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss. (2009)
  • Author(s): Lin Y, Nakashima A, Shima T, Zhou X, Saito S.J
  • Journal Title: Reprod Immunol.2009 83 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Toll-like receptor signaling in uterine natural killer cells--role in embryonic loss. (2009)
  • Author(s): Lin, Y, Nakashima A
  • Journal Title: Journal of reproductive immunology 83 Pages: 95-100
  • Peer Reviewed
• [Presentation] Autophagy is an indispensable mechanism for extravillous trophoblast invasion (2010)
  • Author(s): Saito S, Nakashima A
  • Organizer: 第69回日本癌学会学術総会 “Cancer and autophagy"
  • Place of Presentation: 大阪 国際会議場シンポジウム
• [Presentation] The role of IL-17 in the pathogenesis of preterm labor (2010)
  • Author(s): Nakashima A, Ito M, Shima T, Yoneda S, Saito S, Osaka
  • Organizer: International symposium for immunology of reproduction, symposium "Infectious immunity"
• [Presentation] オートファジーは絨毛外栄養膜細胞に必須の機構である (2010)
  • Author(s): 中島彰俊
  • Organizer: 学術奨励賞第15回日本病態プロテアーゼ学会
  • Place of Presentation: 大阪 千里ライフサイエンスセンター
• [Presentation] Autophagy is an indispensable mechanism for extravillous trophoblast invasion (2010)
  • Author(s): Saito S, Nakashima A
  • Organizer: 第69回 日本癌学会学術集会
  • Place of Presentation: 大阪(シンポジウム)
• [Presentation] T細胞・NK細胞と妊娠維持"シンポジウム「Trophoblastに関わる免疫と臨床病態」 (2009)
  • Author(s): 中島彰俊
  • Organizer: 第17回日本胎盤学会学術集会
  • Place of Presentation: 東京
• [Presentation] オートファジーは絨毛外栄養膜細胞浸潤に必須の機構である (2009)
  • Author(s): 中島彰俊
  • Organizer: 学会賞第17回日本胎盤学会学術集会
  • Place of Presentation: 東京
• [Presentation] The role of autophagy on the invasion of extravillous trophoblast (2009)
  • Author(s): Nakashima A, Tatematsu M, Saito S.
  • Organizer: International Federation of Placenta Associations Adelaide
  • Place of Presentation: Australia
• [Presentation] The role of autophagy on the invasion of extravillous trophoblast (2009)
  • Author(s): 中島彰俊
  • Organizer: 15th IFPA/2nd PAA Conference
  • Place of Presentation: Adelaide, Australia
• [Presentation] "T細胞・NK細胞と妊娠維持"シンポジウム「Trophoblastに関わる免疫と臨床病態」 (2009)
  • Author(s): 中島彰俊
  • Organizer: 日本胎盤学会学術集会
  • Place of Presentation: 東京