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Placenta as a target of influenza virus infection

Research Project

Project/Area Number 21791574
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNihon University

Principal Investigator

AIZAWA Shihoko  Nihon University, 医学部, 助手 (30513858)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords微生物 / 胎盤 / インフルエンザウイルス / 徴生物
Research Abstract

We report here placenta as a target organ of influenza A virus. A choriocarcinoma cell line and immortalized human invasive trophoblasts were challenged with an influenza virus strain A/Udorn/72 and /or clinical isolate of H1N1/09 influenza virus. We observed viral replication in both viruses, while cytotoxicity was less prominent in H1N1/09.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Products Report
  • Research Products

    (4 results)

All 2012 2011 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] H1N1/09 Influenza A Virus Infection of Immortalized First Trimester Human Trophoblast Cell Lines2012

    • Author(s)
      Shihoko Komine-Aizawa, Ai Suzaki, Quang D. Trinh, Yasuyuki Izumi, Toshikatsu Shibata, Kazumichi Kuroda, Satoshi Hayakawa
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 68 Issue: 3 Pages: 226-232

    • DOI

      10.1111/j.1600-0897.2012.01172.x

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis.2009

    • Author(s)
      Trinh QD, Izumi Y, Komine-Aizawa S, Shibata T, Shimotai Y, Kuroda K, Mizuguchi M, Ushijima H, Mor G, Hayakawa S.
    • Journal Title

      Am J Reprod Immunol 62(3)

      Pages: 139-146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis2009

    • Author(s)
      Trinh QD, Izumi Y, Komine-Aizawa S, Shibata T, Shimotai Y, Kuroda K, Mizuguchi M, Ushijima H, Mor G, Hayakawa S
    • Journal Title

      Am J Reprod Immunol 62(3)

      Pages: 139-146

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ブタ由来新型インフルエンザウイルス(H1N1)が初期胎盤絨毛に与える影響2011

    • Author(s)
      相澤志保子、早川智
    • Organizer
      第63回日本産科婦人科学会総会・学術集会(東日本大震災の影響で2011 年8 月29 日に延期となった)
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-04-15
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-09-09  

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