osteoclasts regulate morphology of auditory ossicles and maintaining hearing function

• Project/Area Number: 21791643
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: KANZAKI Sho Keio University, 医学部, 講師 (50286556)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 耳小骨 / 破骨細胞 / 耳硬化症 / 大理石病 / 難聴 / 中耳

Research Abstract

We analyzed hearing function and morphological features of auditory ossicles in osteopetrotic mice, which lack osteoclasts because of the deficiency of either cytokine RANKL or transcription factor c-Fos. Osteopetrotic mice showed severe hearing loss and a smaller volume of the tympanic cavity but had larger auditory ossicles compared with controls. Unexpected contact of ossicles to the otic capsule causes hearing loss.

Research Products

• [Journal Article] Impaired of vibration auditory ossicles in osteopetrotic mice (2011)
  • Author(s): Kanzaki S, Takada Y, Niida S,Takeda Y,Nango N, Momose A, Ogawa K, Matsuo K
  • Journal Title: American Journal of Pathology 178 Pages: 1270-1278
  • Peer Reviewed
• [Journal Article] Impaired vibration of auditory ossicles in osteopetrotic mice (2011)
  • Author(s): Kanzaki S, Takada Y, Niida S, Takeda Y, Nango N, Momose A, Ogawa K, Matsuo K
  • Journal Title: American Journal of Pathology Volume: 178 Pages: 1270-8
  • Peer Reviewed
• [Journal Article] 耳硬化症update (2)-治療と予防- (2010)
  • Author(s): 小川郁、井上泰宏、斎藤秀行、神崎晶、鈴木隆史、大石直樹、岡本康秀(総説)
  • Journal Title: 耳鼻咽喉科臨床 103 Pages: 103-112
  • NAID: 10026216493
  • Peer Reviewed
• [Journal Article] (総説)耳硬化症update(2)-治療と予防- (2010)
  • Author(s): 小川郁、井上泰宏、斎藤秀行、神崎晶、鈴木隆史、大石直樹、岡本康秀
  • Journal Title: 耳鼻咽喉科臨床 Volume: 103 Pages: 103-112
• [Journal Article] Bisphosphonate Therapy Ameliorates Hearing Loss in Mice Lacking Osteoprotegerin. (2009)
  • Author(s): Kanzaki S, Takada Y, et al.
  • Journal Title: J Bone Miner Res. 24(1) Pages: 43-49
  • Peer Reviewed
• [Journal Article] Bisphosphonate therapy ameliorates bone resorption and hearing loss in mice lacking osteoprotegerin (2009)
  • Author(s): Kanzaki S, Ogawa K
  • Journal Title: Proceedings Cholesteatoma and Ear Surgery meeting 15 Pages: 66-69
• [Presentation] Significant correlation between audiogram and perioperative testing ossicular mobility in otosclerosis patients (2010)
  • Author(s): Kanzaki S
  • Organizer: JOINT MEETING-IV CONSENSUS IN AUDITORY IMPLANTS &V EAONO INSTRUCTIONAL WORKSHOP-
  • Place of Presentation: Parma Italy
  • Year and Date: 2010-06-16
• [Presentation] Significant correlation between audiogram and perioperative testing ossicular mobility in otosclerosis patients- (2010)
  • Author(s): Kanzaki S
  • Organizer: JOINT MEETING-IV CONSENSUS IN AUDITORY IMPLANTS &V EAONO INSTRUCTIONAL WORKSHOP-
  • Place of Presentation: Parma
• [Presentation] Motion of tympanic ossicles in mice model measured by a laser doppler vibrometer (2009)
  • Author(s): Kanzaki S
  • Organizer: Laser Tbkyo 2009(Symposium)
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2009-12-03
• [Presentation] 破骨細胞が中耳疾患に与える影響について (2009)
  • Author(s): 神崎晶
  • Organizer: 第13回臨床骨代謝フォーラム((招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2009-07-18
• [Presentation] Bisphosphonate therapy ameliorates bone resorption and hearing loss in mice lacking osteoprotegerin (2009)
  • Author(s): Kanzaki S, et al.
  • Organizer: Cholesteatoma and Ear Surgery meeting, Antalya
  • Place of Presentation: Antalya Turkey
• [Presentation] Abnormal Auditory Ossicles and Hearing Loss in Osteopetrotic Mice (2009)
  • Author(s): Kanzaki S.T
  • Organizer: MidWinter Meeting for the Association for Research in Otolaryngology.
  • Place of Presentation: the Disneyland Hotel in Anaheim, California, USA.
• [Presentation] 破骨細胞数の減少と難聴の関連性について-大理石病マウスモデルを用いた解析 (2009)
  • Author(s): 神崎晶
  • Organizer: 日本耳鼻咽喉科学会
  • Place of Presentation: 東京
• [Remarks] ホームページ等