Regulatory mechanisms of neuronal regeneration in the retina and role of the pars plana.

• Project/Area Number: 21791676
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Nagoya University
• Principal Investigator: NISHIGUCHI Koji Nagoya University, 医学部附属病院, 助教 (30447825)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ヘパラン硫酸 / 血管内皮成長因子 / 糖尿病網膜症 / 網膜変性 / 毛様体上皮 / 網膜 / 視細胞 / 網膜発生

Research Abstract

The high concentration of heparan sulfate found in the intraocular fluid binds to various growth factors and cytokines including vascular endothelial growth factor through heparin-binding domain and thereby inhibits their physiological function. This mechanism proved to inhibit the aberrant invasion of pathological retinal vessels into the vitreous. Furthermore, intraocular heparan sulfate may regulate the development of retinal tissue including the vascular network.

Research Products

• [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin. (2011)
  • Author(s): Tomida D, Nishiguchi KM, Kataoka K, Yasuma TR, Iwata E, Uetani R, Kachi S, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. in press
  • Peer Reviewed
• [Journal Article] The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. (2011)
  • Author(s): Kataoka K, Nishiguchi KM, Kaneko H, van Rooijen N, Kachi S, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. 52 Pages: 1431-1438
  • Peer Reviewed
• [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin (2011)
  • Author(s): Tomida D
  • Journal Title: Invest Ophthalmol Vis Sci
  • Peer Reviewed
• [Journal Article] Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration (2010)
  • Author(s): Yasuma TR, Nakamura M, Nishiguchi KM, Kikuchi M, Kaneko H, Niwa T, Hamajima N, Terasaki H
  • Journal Title: Mol Vis. 16 Pages: 2923-2930
  • Peer Reviewed
• [Journal Article] Regulation of pathologic retinal angiogenesis and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. (2010)
  • Author(s): Nishiguchi KM, Kataoka K, Kachi S, Komeima K, Terasaki H
  • Journal Title: PLoS ONE. 5 Pages: 13493-13493
  • Peer Reviewed
• [Journal Article] TRPM1 mutations are associated with the complete form of congenital stationary night blindness. (2010)
  • Author(s): Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki M, Kondo M, Miyake Y, Furukawa T.
  • Journal Title: Mol Vis. 16 Pages: 425-437
  • Peer Reviewed
• [Journal Article] Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. (2010)
  • Author(s): Nishiguchi KM
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. (2010)
  • Author(s): Kataoka K
  • Journal Title: Invest Ophthalmol Vis Sci
  • Peer Reviewed
• [Journal Article] Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration (2010)
  • Author(s): Yasuma TR
  • Journal Title: Mol Vis Volume: 16 Pages: 2923-2930
  • Peer Reviewed
• [Journal Article] Generation of immature retinal neurons from proliferating cells in the pars plana after retinal histogenesis in mice with retinal degeneration. (2009)
  • Author(s): Nishiguchi KM
  • Journal Title: Mol Vis. 15 Pages: 187-199
  • Peer Reviewed
• [Presentation] Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. (2010)
  • Author(s): 西口康二
  • Organizer: ARVO
  • Place of Presentation: Ft. Lauderdale, FL, USA
  • Year and Date: 2010-05-02
• [Presentation] Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. (2010)
  • Author(s): Nishiguchi KM
  • Organizer: ARVO
  • Place of Presentation: Ft.Lauderdale, FL, USA
  • Year and Date: 2010-05-02
• [Presentation] グリコサミノグリカンによる病的網膜血管新生の抑制 (2010)
  • Author(s): 西口康二
  • Organizer: 第14回眼分子生物学研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-02-13
• [Presentation] グリコサミノグリカンによる病的網膜血管新生の抑制 (2010)
  • Author(s): 西口康二
  • Organizer: 第14回眼分子生物学研究会
  • Place of Presentation: 大阪府池田市
  • Year and Date: 2010-02-13
• [Remarks] ホームページ等