The development of gene therapy for intractable glaucoma using new SIV vector
Project/Area Number |
21791689
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Kyushu University |
Principal Investigator |
MIYAZAKI Masanori Kyushu University, 大学病院・眼科, 助教 (40380638)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 緑内障 / 遺伝子治療 / 治療実験 / 視覚 |
Research Abstract |
We assessed the newly developed SIV-mediated gene therapy using PEDF for two different RGC-damaged glaucoma models. Retinal whole mount and pattern ERG showed morphological and functional rescue of retinal ganglion cells in therapeutic group. These findings show that neuroprotective gene therapy using PEDF can protect ganglion cell death, and support the potential feasibility of neuroprotective therapy of intractable glaucoma.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection.2010
Author(s)
Kohno R, Hata Y, Mochizuki Y, Arita R, Kawahara S, Kita T, Miyazaki M, Hisatomi T, Ikeda Y, Aiello LP, Ishibashi T.
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Journal Title
Am J Ophthalmol. 150(2)
Pages: 223-229
Related Report
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[Journal Article] Acute toxicity study of a simian immunodeficiency virus-based lentiviral vector for retinal gene transfer in nonhuman primates.2009
Author(s)
Ikeda Y, Yonemitsu Y, Miyazaki M, Kohno R, Murakami Y, Murata T, Goto Y, Tabata T, Ueda Y, Ono F, Suzuki T, Ageyama N, Terao K, Hasegawa M, Sueishi K, Ishibashi T.
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Journal Title
Hum Gene Ther. 20(9)
Pages: 943-954
Related Report
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[Journal Article] Stable retinal gene expression in nonhuman primates via subretinal injection of SIVagm-based lentiviral vectors.2009
Author(s)
Ikeda Y, Yonemitsu Y, Miyazaki M, Kohno R, Murakami Y, Murata T, Tabata T, Ueda Y, Ono F, Suzuki T, Ageyama N, Terao K, Hasegawa M, Sueishi K, Ishibashi T.
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Journal Title
Hum Gene Ther. 20(6)
Pages: 573-579
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