Development of Diagnostic Device for Corneal Impairment

• Project/Area Number: 21791692
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Nagasaki University
• Principal Investigator: UEMATSU Masafumi Nagasaki University, 病院, 助教 (30380843)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 角膜 / バリア機能 / 角膜上皮障害 / 塩化ベンザルコニウム / 毒性試験

Research Abstract

A novel diagnostic device for corneal impairment was developed and manufactured, which is applied for an international patent. Measurement of corneal impairment was succeeded using the device. Furthermore, corneal toxicity due to an eyedrop preservative was able to be evaluated.

Research Products

• [Journal Article] Influence of alkyl chain length of benzalkonium chloride on acute corneal epithelial toxicity (2010)
  • Author(s): Uematsu M, Kumagami T, Shimoda K, et al
  • Journal Title: Cornea 29(11) Pages: 1296-1301
  • NAID: 120006984827
  • Peer Reviewed
• [Journal Article] Influence of alkyl chain length of benzalkonium chloride on acute corneal epithelial toxicity (2010)
  • Author(s): Uematsu M, et al
  • Journal Title: Cornea Volume: 29(11) Pages: 1296-1301
  • NAID: 120006984827
  • Peer Reviewed
• [Presentation] ラタノプロスト製剤による角膜バリア機能の変化 (2011)
  • Author(s): 上松聖典, ら
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-12
• [Presentation] A novel in vivo corneal trans-epithelial electrical resistance measurement device (2011)
  • Author(s): Uematsu M, et al
  • Organizer: Association for Research and Vision and Ophthalmology, 2011 Annual Meeting
  • Place of Presentation: Fort Lauderdale, Florida
  • Year and Date: 2011-05-01
• [Presentation] A novel in vivo corneal trans-epithelial electrical resistance measurement device Association for Research and Vision and Ophthalmology (2011)
  • Author(s): Uematsu M, Tanaka Y, Sekine S, et al
  • Organizer: 2011 Annual Meeting
  • Place of Presentation: アメリカ合衆国
• [Presentation] ラタノプロスト製剤による角膜バリア機能の変化 (2011)
  • Author(s): 上松聖典、手嶋無限、市丸哲郎, ら
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 臨床応用できる角膜バリア機能測定装置の開発 (2010)
  • Author(s): 上松聖典, ら
  • Organizer: 第34回角膜カンファランス
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-02-11
• [Remarks] ホームページ等w
• [Patent(Industrial Property Rights)] 角膜経上皮電気抵抗値の測定方法( Method of Measuring Electrical Resistance Value of Corneal Trans-Epithelium ) (2009)
  • Inventor(s): 上松聖典、北岡隆、西田幸二, ら
  • Industrial Property Rights Holder: 長崎大学, 東北大学
  • Industrial Property Number: 2010-501917
  • Filing Date: 2009-03-03
• [Patent(Industrial Property Rights)] 角膜経上皮電気抵抗値の測定方法(Method of Measuring Electrical Resistance Value of Cornral Trans-Epithelium) (2009)
  • Inventor(s): Uematsu M, et al.
  • Industrial Property Rights Holder: 長崎大学 東北大学
  • Industrial Property Number: 2010-501917
  • Filing Date: 2009-03-03