Involvement of endoplasmic reticulum stress in retinitis pigmentosa, and analysis of its molecular mechanism
| Project/Area Number |
21791699
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 網膜色素変性症 / SEMA4A / 酸化ストレス / 小胞体ストレス / 光障害 / 網膜色素上皮細胞 |
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| Research Abstract |
SEMA4A mutants, known as a responsible gene of retinitis pigmentosa(RP), lead to susceptibility to white light irradiation, oxidative stress and endoplasmic reticulum(ER) stress in RPE cell line and zebrafish. These results suggest that ER stress is an exacerbating factor of RP and will be a novel therapeutic target for RP.
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Report
(4 results)
Research Products
(7 results)
