Involvement of endoplasmic reticulum stress in retinitis pigmentosa, and analysis of its molecular mechanism

• Project/Area Number: 21791699
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: TSURUMA Kazuhiro 岐阜薬科大学, 薬学部, 助教 (50524980)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 網膜色素変性症 / SEMA4A / 酸化ストレス / 小胞体ストレス / 光障害 / 網膜色素上皮細胞

Research Abstract

SEMA4A mutants, known as a responsible gene of retinitis pigmentosa(RP), lead to susceptibility to white light irradiation, oxidative stress and endoplasmic reticulum(ER) stress in RPE cell line and zebrafish. These results suggest that ER stress is an exacerbating factor of RP and will be a novel therapeutic target for RP.

Research Products

• [Presentation] 網膜障害における小胞体ストレスの関与 (2011)
  • Author(s): 鶴間一寛、原英彰
  • Organizer: 第6回小胞体ストレス研究会
  • Place of Presentation: 岡山
  • Year and Date: 2011-10-28
• [Presentation] 網膜障害における小胞体ストレスの関与 (2011)
  • Author(s): 鶴間一寛
  • Organizer: 第6回小胞体ストレス研究会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-10-28
• [Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress (2010)
  • Author(s): 鶴間一寛(Kazuhiro Tsuruma)
  • Organizer: Neuroscience 2010
  • Place of Presentation: アメリカ サンディエゴ
  • Year and Date: 2010-11-13
• [Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と光ストレスと小胞体ストレスの関連 (2010)
  • Author(s): 鶴間一寛、原英彰
  • Organizer: 第5回小胞体ストレス研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-29
• [Presentation] 網膜色素変性症における変異型SEMA4Aと小胞体ストレスの関与 (2010)
  • Author(s): 鶴間一寛、嶋澤雅光、原英彰
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島
  • Year and Date: 2010-07-08
• [Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress (2010)
  • Author(s): Tsuruma K., Shimazawa M. and Hara H
  • Organizer: Neuroscience
  • Place of Presentation: San Diego, California
• [Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と小胞体ストレスの関与 (2010)
  • Author(s): 鶴間一寛、嶋澤雅光、原英彰
  • Organizer: 第30回日本眼薬理学会
  • Place of Presentation: 東京