Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Research Abstract |
SEMA4A mutants, known as a responsible gene of retinitis pigmentosa(RP), lead to susceptibility to white light irradiation, oxidative stress and endoplasmic reticulum(ER) stress in RPE cell line and zebrafish. These results suggest that ER stress is an exacerbating factor of RP and will be a novel therapeutic target for RP.
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