The new methods for suppression of blood vessel maturation and lymphangiogensis

• Project/Area Number: 21791702
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MARUYAMA Kazuichi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (10433244)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 細胞・組織 / 癌 / 発生・分化

Research Abstract

Podoplanin Fc protein could suppress corneal hem-and lymphangiogenesis. Also, it could suppress vessel maturation in cornea. Podoplanin Fc protein injection into peritoneal cavity suppressed the retinal vessel maturation during post-natal stage.
In migration assay, podoplanin Fc protein and PDGF-BB neutralizing antibody could suppress pericyte migration toward to blood vessel endothelium.
In conclusion, to control podoplanin function could suppress blood vessel maturation and lymphangiogenesis

Research Products

• [Journal Article] Lymphangiogenesis and angiogenesis : concurrence and/or dependence? Studies in inbred mouse strains. (2010)
  • Author(s): Nakao S, Maruyama K, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A.
  • Journal Title: FASEB Journal 24 Pages: 504-513
• [Journal Article] Genetic heterogeneity of lymphangiogenesis in different mouse strains. (2010)
  • Author(s): Regenfuss B, Onderka J, Bock F, Hos D, Maruyama K, Cursiefen C.
  • Journal Title: American Journal of Pathology 177 Pages: 501-510
• [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis. (2010)
  • Author(s): Matsuda A, Ebihara N, Yokoi N, Maruyama K, Hamuro J, Kinoshita S, Murakami A.
  • Journal Title: J Allergy Clin Immunol 177 Pages: 1310-1312
• [Journal Article] Lymphangiogenesis and angiogenesis : concurrence and/or dependence? Studies in inbred mouse strains. (2010)
  • Author(s): Nakao S, Maruyama K, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A.
  • Journal Title: FASEB Journal Volume: 24 Pages: 504-513
  • Peer Reviewed
• [Journal Article] Genetic heterogeneity of lymphangiogenesis in different mouse strains. (2010)
  • Author(s): Regenfuss B, Onderka J, Bock F, Hos D, Maruyama K, Cursiefen C.
  • Journal Title: American Journal of Pathology Volume: 177 Pages: 501-510
  • Peer Reviewed
• [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis. (2010)
  • Author(s): Matsuda A, Ebihara N, Yokoi N, Maruyama K, Hamuro J, Kinoshita S, Murakami A.
  • Journal Title: J Allergy Clin Immunol Volume: 126 Pages: 1310-1312
  • Peer Reviewed
• [Journal Article] A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis : British (2009)
  • Author(s): Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruyama K, Kinoshita S, Mochizuki M.
  • Journal Title: Journal of Ophthalmology 94(3) Pages: 336-340
• [Journal Article] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions (2009)
  • Author(s): Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M.
  • Journal Title: Journal of Immunology 183(8) Pages: 5013-5022
• [Journal Article] Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease, British (2009)
  • Author(s): Koizumi H, Maruyama K, Kinoshita S
  • Journal Title: Journal of Ophthalmology
• [Journal Article] Intracellular Thiol Redox Status Regulates Lymphatic Vessel Growth in the Cornea and Dictates Corneal Limbal Graft Survival. (2009)
  • Author(s): Fukumoto A, Maruyama K, Walsh T, Kajiya K, Hamuro J, D'Amore PA, Kino shita S
  • Journal Title: Investigative Vision and Ophthalmology
• [Journal Article] A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis (2009)
  • Author(s): Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruvama K, Kinoshita S, Mochizuki M.
  • Journal Title: British Journal_of Ophthalmology 94(3) Pages: 336-340
  • Peer Reviewed
• [Journal Article] Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Koizumi H, Maruyama K, Kinoshita S
  • Journal Title: British Journal of Ophthalmology (Epub ahead of prin)
  • Peer Reviewed
• [Journal Article] Intracellular Thiol Redox Status Regulates Lymphatic Vessel Growth in the Cornea and Dictates Corneal Limbal Graft Survival. (2009)
  • Author(s): Fukumoto A, Maruyama K, Walsh T, Kajiya K, Hamuro J, D'Amore PA, Kinoshita S
  • Journal Title: British Journal of Ophthalmology (Epub abead of prin)
  • Peer Reviewed
• [Presentation] Podoplanin regulates corneal epithelial cell proliferation and morphology (2010)
  • Author(s): Kazuichi Maruyama
  • Organizer: ARVO
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2010-05-06
• [Presentation] Podoplanin regulates corneal epithelial cell proliferation and morphology (2010)
  • Author(s): Kazuichi Maruyama
  • Organizer: ARVO 2010
  • Place of Presentation: Ft.Lauderdale
• [Presentation] Podoplanin中和抗体による角膜リンパ管新生と角膜移植後拒絶反応の抑制 (2009)
  • Author(s): 丸山和一、Dontcho Kerjaschki、Patricia D'Amore、木下茂
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 東京
• [Remarks] ホームページ等
  • URL: http://www.ophth.kpu-m.ac.jp/introduction/maruyama/