The new methods for suppression of blood vessel maturation and lymphangiogensis
| Project/Area Number |
21791702
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MARUYAMA Kazuichi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (10433244)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞・組織 / 癌 / 発生・分化 |
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| Research Abstract |
Podoplanin Fc protein could suppress corneal hem-and lymphangiogenesis. Also, it could suppress vessel maturation in cornea. Podoplanin Fc protein injection into peritoneal cavity suppressed the retinal vessel maturation during post-natal stage.
In migration assay, podoplanin Fc protein and PDGF-BB neutralizing antibody could suppress pericyte migration toward to blood vessel endothelium.
In conclusion, to control podoplanin function could suppress blood vessel maturation and lymphangiogenesis
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions2009
Author(s)
Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M.
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Journal Title
Journal of Immunology 183(8)
Pages: 5013-5022
Related Report
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