Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.

• Project/Area Number: 21791781
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: NAGAI Yasuhiro Tohoku University, 大学院・歯学研究科, 助教 (90508962)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 免疫 / 肥満 / アレルギー / 舌下免疫 / 金属アレルギー / 食事性肥満 / 免疫寛容 / 免疫不応答

Research Abstract

Evidence from population studies shows that obesity clearly exacerbates a health risk. In this study we investigated the effects of diet-induced obesity on nickel allergy and anaphylactic shock and obtained the results below ; 1. Diet-induced obesity significantly reduced nickel allergy reaction. 2. Sublingual immunotherapy significantly reduces nickel allergy in normal mice, but there is no difference in obesity mice. OVA-induced anaphylactic shock did not occur in obesity mice.

Research Products

• [Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate. (2010)
  • Author(s): Shikama Y, Nagai Y, Okada S1, Oizumi T, Shimauchi H, Sugawara S, Endo Y.
  • Journal Title: Toxicol Lett 199(2) Pages: 123-128
  • Peer Reviewed
• [Journal Article] Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1 and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). (2009)
  • Author(s): Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada T, Sugawara S, Endo Y.
  • Journal Title: Innate Immunity 17(1) Pages: 3-15
  • Peer Reviewed
• [Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice. (2009)
  • Author(s): Kuroishi T, Kinbara M, Sato N, Tanaka Y, Nagai Y, Iwakura Y, Endo Y, Sugawara S.
  • Journal Title: Journal of Nutrition 139 Pages: 1031-1036
  • Peer Reviewed
• [Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice (2009)
  • Author(s): Kuroishi T, Kinbara M, Sato N, Tanaka Y, Nagai Y, Iwakura Y, Endo Y, Sugawara S.
  • Journal Title: Journal of Nutrition 139 Pages: 1031-1036
  • Peer Reviewed
• [Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells. (2010)
  • Author(s): Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S.
  • Organizer: 8th joint conference of the ICS and ISICR
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-10-05
• [Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells (2010)
  • Author(s): Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S
  • Organizer: 8^<th> joint conference of the ICS and ISICR
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-10-05
• [Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy. (2010)
  • Author(s): Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S.
  • Organizer: 8th joint conference of the ICS and ISICR
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-10-04
• [Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy (2010)
  • Author(s): Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-10-04
• [Presentation] マウスNiアレルギーにおける免疫記憶型CD3+NK1.1+細胞の関与 (2010)
  • Author(s): 永井康裕、金原正敬、田中志典、遠藤康男、菅原俊二
  • Organizer: 第52回歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-09
• [Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells. (2010)
  • Author(s): Nagai Y., Tanaka Y., Endo Y., Sugawara S.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells (2010)
  • Author(s): Nagai Y., Tanaka Y., Endo Y., Sugawara S
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] Induction of Treg from PBMC by interacting with immunosuppressive B7-H3 molecule on oral mesenchymal stem cells from human gingival fibroblasts. (2009)
  • Author(s): Nagai Y., Shiraishi D., Ohki A., Tanaka Y., Aso H., Sugawara S.
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy (2009)
  • Author(s): Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S.
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Analysis of antigen incorporating and processing cells in subling al immunotherapy (2009)
  • Author(s): Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] 舌下粘膜の抗原取り込み機構と舌下粘膜免疫療法 (2009)
  • Author(s): 白石大祐、永井康裕、遠藤康男、島内英俊、菅原俊二
  • Organizer: 第51回歯科基礎医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-09
• [Presentation] ヒト歯肉由来間葉系幹細胞が発現するB7-H3分子による制御性T細胞誘導とその機能解析 (2009)
  • Author(s): 永井康裕、黒石智誠、白石大祐、大木亜紀子、島内英俊、菅原俊二
  • Organizer: 第51回歯科基礎医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-09
• [Remarks] ホームページ等