Role of retinoic acid catabolising enzyme in craniofacial development
Project/Area Number |
21791785
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
|
Research Institution | Osaka University |
Principal Investigator |
ABE Makoto Osaka University, 歯学研究科, 助教 (40448105)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 口腔解剖学 / 口腔顔面発生 / レチノイン酸 / Trps1 / 顎関節 / 頭蓋顔面 / Runx2 / 頭蓋顔面発生 / 鰓弓 / Cyp26B1 / パターニング / 転写因子 |
Research Abstract |
In order to understand the molecular mechanisms of normal craniofacial development, microarray analysis was performed using pharyngeal arches from wild type and Cyp26B1 knockout embryos. Number of molecules was identified to be up- or down-regulated. Trps1 was one of the molecules those were down-regulated in Cyp26B1 knockout mice. Trps1 knockout mice showed craniofacial deformities partially overlapping the defects observed in Cyp26B1 knockout mice.
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Report
(3 results)
Research Products
(15 results)