| Project/Area Number |
21791793
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SATO Keiko Nagasaki University, 医歯薬学総合研究科, 助教 (70410579)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 歯周病原細菌 / タンパク質分泌装置 / プロテアーゼ / Porphyromonas gingivalis / Bacteroidetes phylum / 病原因子 / 分泌機構 / ジンジパイ |
|---|
| Research Abstract |
Porphyromonas gingivalis is an oral anaerobic Gram-negative bacterium, which is implicated in periodontal pathogenesis. Most of proteolytic activity of extracellular and cell-surface proteinase are derived from cysteine proteinase named gingipains. We found a novel protein secretion system in bacteria of the phylum Bacteroidetes, which is responsible for secretion of virulence factors such as gingipain proteinases produced from the periodontal pathogen Porphyromonas gingivalis and is linked to bacteroidete gliding motility that is distinct from other well-studied forms of bacterial movement.
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