バクテロデスフィラムに位置する細菌の菌体外蛋白質分泌機構の解明
Project/Area Number |
21791793
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
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Research Institution | Nagasaki University |
Principal Investigator |
SATO Keiko Nagasaki University, 医歯薬学総合研究科, 助教 (70410579)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 歯周病原細菌 / タンパク質分泌装置 / プロテアーゼ / Porphyromonas gingivalis / Bacteroidetes phylum / 病原因子 / 分泌機構 / ジンジパイ |
Research Abstract |
Porphyromonas gingivalis is an oral anaerobic Gram-negative bacterium, which is implicated in periodontal pathogenesis. Most of proteolytic activity of extracellular and cell-surface proteinase are derived from cysteine proteinase named gingipains. We found a novel protein secretion system in bacteria of the phylum Bacteroidetes, which is responsible for secretion of virulence factors such as gingipain proteinases produced from the periodontal pathogen Porphyromonas gingivalis and is linked to bacteroidete gliding motility that is distinct from other well-studied forms of bacterial movement.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization(共著)2010
Author(s)
hoji M, Shibata Y, Shiroza T, Yukitake H, Peng B, Chen Y-Y, Sato K, Naito M, Abiko Y, Reynolds EC, Nakayama K
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Journal Title
BMC Microbiology 10巻
Pages: 152-152
Related Report
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[Journal Article] Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis : its cellular distribution, thioredoxin activity and role in hemeutilization.2010
Author(s)
Shoji M, Shibata Y, Shiroza T, Yukitake H, Peng B, Chen Y-Y, Sato K, Naito M, Abiko Y, Reynolds EC, Nakayama K
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Journal Title
BMC Microbiol
Volume: 10
Pages: 152-152
Related Report
Peer Reviewed
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