Elucidation of Toll-like receptor mediated immune activation effects induced by oral gram-positive bacteria

• Project/Area Number: 21791796
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: KATAOKA Hideo 昭和大学, 歯学部, 助教 (60451390)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 口腔細菌学 / 感染症 / 微生物 / 細菌 / 歯学 / 免疫学

Research Abstract

It has not been shown the detail molecular mechanisms of inducing periodontal inflammation by oral gram-positive bacteria. In this study, we showed a molecular mechanism that bacterial lipoproteins of Oral Streptococci and Actinomyces induce inflammatory responses via Toll-like receptor 2 in host cells. This finding suggests that these bacterial lipoproteins could be an inducing factor of periodontal inflammation.

Research Products

• [Journal Article] Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages (2012)
  • Author(s): Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T
  • Journal Title: Microbes and Infection Volume: (In press) Issue: 11 Pages: 916-921
  • DOI: 10.1016/j.micinf.2012.04.015
  • Peer Reviewed
• [Presentation] Roles of lipoproteins in clearance of oral streptococci (2012)
  • Author(s): 瀬川卓
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール長崎新聞文化ホール
  • Year and Date: 2012-03-27
• [Presentation] Modulation of growth and functions of CD4+CD25+Foxp3+ regulatory T cells by oral streptococci (2012)
  • Author(s): 佐伯歩
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール長崎新聞文化ホール
  • Year and Date: 2012-03-27
• [Presentation] 制御性T細胞(Treg)の免疫抑制活性に及ぼす口腔連鎖球菌の影響 (2011)
  • Author(s): 佐伯歩
  • Organizer: 第53回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2011-09-30
• [Presentation] 口腔連鎖球菌の生体からの排除におけるリポタンパク質の影響 (2011)
  • Author(s): 瀬川卓
  • Organizer: 第53回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2011-09-30
• [Presentation] Induction of TLR2-dependent inflammatory responses by Actinomyces viscosus. (2010)
  • Author(s): 島田絵里
  • Organizer: 第30回昭和歯学会総会
  • Place of Presentation: 昭和大学(東京)
  • Year and Date: 2010-07-03
• [Presentation] Lipoproteins of human cariogenic bacteria are responsible for inflammation-inducing activity mediated by Toll-like receptor 2 (2009)
  • Author(s): Kataoka H, Takahashi M, Shibata Y, Igarashi T
  • Organizer: 3^<rd> Congress of European Microbiologists
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] Lipoproteins of human cariogenic bacteria are responsible for inflammation-inducing activity mediated by Toll-like receptor 2 (2009)
  • Author(s): 片岡嗣雄
  • Organizer: 第3回ヨーロッパ微生物学会(FEMS2009)
  • Place of Presentation: Gothenburg Convention Centre (Sweden)