Elucidation of Toll-like receptor mediated immune activation effects induced by oral gram-positive bacteria
| Project/Area Number |
21791796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口腔細菌学 / 感染症 / 微生物 / 細菌 / 歯学 / 免疫学 |
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| Research Abstract |
It has not been shown the detail molecular mechanisms of inducing periodontal inflammation by oral gram-positive bacteria. In this study, we showed a molecular mechanism that bacterial lipoproteins of Oral Streptococci and Actinomyces induce inflammatory responses via Toll-like receptor 2 in host cells. This finding suggests that these bacterial lipoproteins could be an inducing factor of periodontal inflammation.
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Report
(4 results)
Research Products
(8 results)
