Development of hyposensitization therapy applying the recombinant oral bacteria secreting the allergen of hey fever.

• Project/Area Number: 21791798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Nihon University
• Principal Investigator: KUWAHARAN Oriko Nihon University, 松戸歯学部, 講師 (90287665)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 口腔細菌学 / アレルギー / スギ花粉症 / 減感作療法 / 組換え体 / 組み換え体

Research Abstract

In this application, i) "Construction of recombinant Streptococcus anginosus strain which can express stabilizing the recombinant allergen of hay fever caused by cedar pollen" and ii) "Colonization of the recombinant S. anginosus, and the induction of immune response mechanism against allergen of hay fever caused by cedar pollen which secreted from recombinant bacteria using the laboratory animal" were examined.
The aim i) was accomplished, but the aim ii) was underway.

Research Products

• [Journal Article] Streptococcus ursoris sp.nov., isolated from the oral cavities of bears. (2011)
  • Author(s): N.Shinozaki-Kuwahara, K.Takada, M.Hirasawa
  • Journal Title: Int.J.System.Evol.Microbiol. 61 Pages: 40-44
  • Peer Reviewed
• [Journal Article] Streptococcus ursoris sp.nov., isolated from the oral cavities of bears. (2011)
  • Author(s): Noriko Shinozaki-Kuwahara, et al
  • Journal Title: International Journal of Systematic and Evolutionary Microbiology. Volume: 61 Pages: 40-44
  • Peer Reviewed
• [Presentation] クマ口腔由来Streptococcus ursoris gtf遺伝子の解析 (2010)
  • Author(s): 篠崎紀子
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2010-09-22
• [Presentation] Analyses of water-soluble glucan synthesized glucosyltransferase gene from Streptococcus dentirousetti (2010)
  • Author(s): Noriko Shinozaki-Kuwahara, et al
  • Organizer: 第88回国際歯科研究会議(IADR)
  • Place of Presentation: Barcelona国際会議場(スペイン)
  • Year and Date: 2010-07-16
• [Presentation] クマ口腔由来Strepcoccus ursoris gtf遺伝子の解析 (2010)
  • Author(s): 篠崎紀子、高田和子、平澤正知
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京)
• [Presentation] Analyses of water-soluble glucan synthesized glucosyltransferasegene from Streptococcus dentirousetti. (2010)
  • Author(s): N.Shinozaki-Kuwahara, K.Takada, M.Hirasawa
  • Organizer: The 88^<th> International Association for Dental Research
  • Place of Presentation: Barcelona(Spain)
• [Presentation] S.dentirousettiが産生する水溶性グルカン合成酵素遺伝子の解析 (2009)
  • Author(s): 篠崎紀子
  • Organizer: 第51回菌科基礎医学会学術大会
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 2009-09-11
• [Presentation] Streptococcus dentirousettiが産生する水溶性グルカン合成酵素遺伝子の解析 (2009)
  • Author(s): 篠崎紀子、高田和子、平澤正知
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟コンベンションセンター(新潟)