| Project/Area Number |
21791807
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKEUCHI Hiroshi Kyushu University, 大学院・歯学研究院, 准教授 (70304813)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | シグナル伝達 / 脂質 / 開口分泌 |
|---|
| Research Abstract |
In this study, we examined the role of PRIP in regulated exocytosis, the universal cellular process through which various hormones, neurotransmitters and cytokines are secreted. We discovered that PRIP negatively regulates exocytosis by competing for membrane phospholipid, PtdIns(4,5)P_2 with a Ca^<2+>-dependent priming factor, CAPS. We also found that PRIP can also inhibit exocytosis independent of its PtdIns(4,5)P_2-binding ability.
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