The effect of copper transporters on the resistance mechanisms of the cisplatin-resistant cancer cell

• Project/Area Number: 21791829
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: MATSUMOTO Shinobu 九州歯科大学, 歯学部, 助教 (20514996)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: シスプラチン / 抗癌剤耐性 / 銅トランスポーター

Research Abstract

Cisplatin(CDDP) is one of the most effective anticancer drug and has been widely used to treat a variety of solid tumors. However, acquired resistance to CDDP limits its clinical use. Recently, it has been suggested that CDDP uptake might be mediated by the copper efflux transporters ATP7A and ATP7B, and the copper influx transporter CTR1.An investigation was carried out as whether copper affected the intracellular accumulation of CDDP and whether changes in the expression of ATP7A and CTR1 were related to acquired resistance. As a result, a high concentration of copper was associated with increases in cellular accumulation of DNA, but did not increase CTR1 expression in CDDP-sensitive or-resistant cells. The acquisition of CDDP resistance in human epidermoid cancer cells was accompanied by a greatly reduced level of ATP7A.

Research Products

• [Journal Article] Importance of magnetic resonance imaging for evaluation of a child with prominent swelling of the facial region after trauma : report of a case (2011)
  • Author(s): Matsumoto-Takeda S, Yamamoto N, Nishida I, Saeki K, Oda M, Yamauchi K, Miyamoto I, Tanaka T, Kito S, Wakasugi-Sato N, Seta Y, Shiiba S, Matsumoto Y, Yamashita Y, Maki K, Takahashi T, Morimoto Y
  • Journal Title: Dent Traumatol Volume: 27 Issue: 4 Pages: 300-4
  • DOI: 10.1111/j.1600-9657.2011.00985.x
  • Peer Reviewed
• [Journal Article] Noninvasive identification of peripheral vessels of oral and maxillofacial regions using electrocardiography-triggered three-dimensional fast asymmetric spin-echo sequences (2011)
  • Author(s): Tanaka T, Oda M, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Otsuka K, Yoshioka I, Habu M, Kokuryo S, Kodama M, Nogami S, Miyamoto I, Yamamoto N, Ishikawa A, Matsuo K, Shiiba S, Seta Y, Yamashita Y, Takahashi T, Tominaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 112(4) Issue: 4 Pages: 493-501
  • DOI: 10.1016/j.tripleo.2011.02.047
  • Peer Reviewed
• [Journal Article] Diagnostic significance of characteristic findings on ultrasonography for the stitch abscess after surgery in patients with oral squamous cell carcinoma (2011)
  • Author(s): Yamamoto N, Yamashita Y, Tanaka T, Ishikawa A, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Oda M, Miyamoto I, Yamauchi K, Shiiba S, Seta Y, Matsuo K, Koga H, Takahashi T, Morimoto Y
  • Journal Title: Oral Oncol Volume: 47 Issue: 3 Pages: 163-9
  • DOI: 10.1016/j.oraloncology.2010.10.015
  • Peer Reviewed
• [Journal Article] Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma (2010)
  • Author(s): Wakasugi-Sato N, Wakasugi T, Oda M, Yamashita Y, Yoshioka I, Yamamoto N, Habu M, Kodama M, Kokuryo S, Ichimiya H, Miyamoto I, Tanaka T, Kito S, Matsumoto-Takeda S, Ishikawa A, Seta Y, Matsuo K, Takahashi T, Tominaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 109 Issue: 6 Pages: 78-85
  • DOI: 10.1016/j.tripleo.2010.01.011
  • Peer Reviewed
• [Journal Article] Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma. (2010)
  • Author(s): Wakasugi-Sato N, Wakasugi T, Oda M, Yamashita Y, Yoshioka I, Yamamoto N, Habu M, Kodama M, Kokuryo S, Ichimiya H, Miyamoto I, Tanaka T, Kito S, Matsumoto-Takeda S, et al.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 109
  • Peer Reviewed
• [Journal Article] Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography (2009)
  • Author(s): Tanaka T, Sakamoto E, Shiiba S, Oda M, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Imamura Y, Nakanishi O, Morimoto Y
  • Journal Title: Clin J Pain Volume: 25(9) Issue: 9 Pages: 752-9
  • DOI: 10.1097/ajp.0b013e3181ada29c
  • Peer Reviewed
• [Presentation] A case report of a child with prominent swelling in mental regions after trauma (2011)
  • Author(s): Shinobu Matsumoto
  • Organizer: The 18th International Congress of DentoMaxilloFacial Radiology
  • Place of Presentation: 広島
  • Year and Date: 2011-05-29
• [Presentation] A case report of a child with prominent swelling in mental regions after trauma (2011)
  • Author(s): Matsumoto-Takeda S, Oda M, Otsuka K, Wakasugi-Sato N, Kito S, Tanaka T, Soga T, Arizumi T, Morimoto Y
  • Organizer: The 18th International Congress of Dentomaxillofacial Radiology
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Usefulness of examination of thyroid glands by ultrasonography for patients with oral squamous cell carcinoma (2011)
  • Author(s): Morimoto Y, Wakasugi-Sato N, Shiki K, Oda M, Tanaka T, Kito S, Matsumoto-Takeda S, Otsuka K, Watanabe T, Ideguchi T, Momozono A
  • Organizer: The 18th International Congress of Dentomaxillofacial Radiology
  • Place of Presentation: Hiroshima, Japan
• [Presentation] A rare case of septic arthritis of the TMJ without malocclusion (2011)
  • Author(s): Kito S, Tanaka T, Wakasugi-Sato N, Matsumoto-Takeda S, Otsuka K, Oda M, Uchida A, Hiromatsu T, Goya T, Kozono T, Morimoto Y
  • Organizer: The 18th International Congress of Dentomaxillofacial Radiology
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Utility of ultrasonography for diagnosis if stitch abscess after surgery of oral cancer (2011)
  • Author(s): Tanaka T, Yamamoto N, Kito S, Matsumoto-Takeda S, Wakasugi-Sato N, Otsuka K, Oda M, Imamura Y, Haraoka T, Ono I, Nishio Y, Miyamoto I, Yamashita Y, Takahashi T, Morimoto Y
  • Organizer: The 18th International Congress of Dentomaxillofacial Radiology
  • Place of Presentation: Hiroshima, Japan
• [Presentation] 小児のオトガイ部外傷評価におけるMRIの有効性 (2010)
  • Author(s): 時津高俊、小田昌史, 松本忍(武田忍), 若杉奈緒(佐藤奈緒), 鬼頭慎司, 田中達朗, 滝野正義, 濱井祐昭, 深井康弘, 内田朱美, 廣松辰巳, 森本泰宏
  • Organizer: 日本歯科放射線学会第49回九州・第53回関西合同地方会
  • Place of Presentation: 北九州
  • Year and Date: 2010-12-11
• [Presentation] Investigation of Thyroid Glands in Oral SCC Patients by US. (2010)
  • Author(s): Wakasugi-Sato N, Tanaka T, Kito S, Matsumoto-Takeda S, Morimoto Y
  • Organizer: 第58回JADR学術大会
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2010-11-20
• [Presentation] FDG高集積を認め診断に苦慮したアミロイド沈着を伴う下顎骨骨髄炎の一例 (2009)
  • Author(s): 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 広松辰巳, 田中達朗, 森本泰宏
  • Organizer: 日本歯科放射線学会第29回関西・九州合同地方会
  • Place of Presentation: 岡山
  • Year and Date: 2009-11-28
• [Presentation] ソフト開発による歯科疾患の客観的評価への提案 (2009)
  • Author(s): 松本忍, 田中達朗, 若杉奈緒, 小田昌史, 鬼頭慎司, 森本泰宏
  • Organizer: 歯工学連携キックオフシンポジウム
  • Place of Presentation: 北九州
  • Year and Date: 2009-01-16
• [Book] Squamous Cell Carcinomas, Dynamic alteration of nucleolin and AgNOR proteins in oral cancer apoptotic cells by ultraviolet rays irradiation (2011)
  • Author(s): Kito S, Shiiba S, Oda M, Tanaka T, Seta Y, Wakasugi-Sato N, Matsumoto-Takeda S, Yoshioka I, Morimoto Y
  • Publisher: Nova Science Publishers
• [Book] Oral Cancer : Causes, Diagnosis and Treatment, Recent advances of the diagnostic images for oral cancers (2011)
  • Author(s): Oda M, Tanaka T, Kito S, Seta Y, Ishikawa A, Kodama M, Yamamoto N, Habu M, Miyamoto I, Kokuryo S, Khanal A, Basugi A, Wakasugi-Sato N, Matsumoto-Takeda S, Hamai M, Mandai S, Takino S, Matsuo K, Yamashita Y, Yoshioka I, Sakoda S, Takahashi T, Tominaga K, Koga H, Morimoto Y
  • Publisher: Nova Science Publishers
• [Book] In Computed Tomography-Special Applications, Application of CT for the study of pathology of the jaws (2011)
  • Author(s): Tanaka T, Kito S, Ishikawa A, Kokuryo S, Yamamoto N, Habu M, Miyamoto I, Kodama M, Matsumoto-Takeda S, Oda M, Wakasugi-Sato N, Otsuka K, Shiiba S, Seta Y, Yamashita Y, Yoshioka I, Matsuo K, Takahashi T, Tominaga K, Morimoto Y
  • Publisher: InTech Open access
• [Book] 臨床研修歯科医必修マニュアル第2版 (2010)
  • Author(s): 森本泰宏、田中達朗、松本忍
  • Publisher: 医歯薬出版