| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this experiment bisphosphonates reduced the adherent strength of osteoclast precursors which are in the process of osteoclast differentiation. Because antibody against adhesion molecules altered osteoclastgenesis, I tried to find the signaling molecules which integrate adhesion molecules and osteoclastgenesis. Syk and Fyn, tyrosine kinases known to be important for osteoclastgenesis, were co-immunoprecipitated with integrins in the process of osteoclastgenesis. These results suggest that outside-in signals from integrins are important for osteoclast-precursor function and differentiation.
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