| Project/Area Number |
21791862
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
|
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIUCHI Noboru 奥羽大学, 歯学部, 教授 (00107294)
KATO Yasumasa 奥羽大学, 歯学部, 教授 (50214408)
KIMURA Yuichi 奥羽大学, 歯学部, 教授 (60211877)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MTAセメント / スタチン / 石灰化 / メバロン酸 / 骨芽細胞 / Rho / MTA / セメント芽細胞 / 再生 / 分化制御 / PI3K / Akt |
|---|
| Research Abstract |
Mineral trioxide aggregate and statins strongly induce mineralization in osteoblasts and stem cells. MTA promoted the gene expression of alkaline phosphatase and osteopontin and enhanced alkaline phosphatase activity throughout the culture period, whereas it markedly inhibited the gene expression of type I collagen. In this study, promoted mineralization of statins, was not strong compared with MTA. However, statin stimulated osteoblastic differentiation while inhibited adipocyte differentiation.
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