| Project/Area Number |
21791928
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
|
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| Co-Investigator(Renkei-kenkyūsha) |
MOCHIDA Yoshiyuki ボストン大学, 歯学部, 准教授
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 骨再生誘導 / 石灰化 / 骨芽細胞 / G11 / 抗体 |
|---|
| Research Abstract |
Implant treatment is predictable to restore edentulous areas after teeth are lost. A development of less-invasive guided bone regeneration method has been required, since the amount of bone of edentulous area is inadequate in many cases. In this study, a possibility of bone formation by an extracellular protein G11(von Willebrand factor C domain containing 2, Vwc2) was examined. As a result, the pattern of newly formed bone-like tissues in G11 group was different from that in control group, though the difference in amount was unclear. Since G11 might induce ectopic bone formations, it is indicated that G11 may contribute to the effective guided bone regeneration through propriety of protein amount and administration method.
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