Development of multi-functional nano carbons for bio applications
Project/Area Number |
21791929
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
ABE Shigeaki 北海道大学, 大学院・歯学研究科, 助教 (40374566)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | カーボンナノチューブ / フラーレン / 体内動態 / 歯科用材料・歯科理工学 / 歯科用材料 / 生体適合性 |
Research Abstract |
In this study, visualization of biodistribution of nano carbon materials, such as fullerene and carbon nanotube(CNT), was investigated to elucidate the biocompatibility. To administer and visualize the biodistribution in mice, bio-injectable nanocarbon materials dispersion was prepared through chemical modification. The injected materials were reached some organs and then detected by some electron microscopic observation. Their cytotoxicity were also determined.
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Report
(4 results)
Research Products
(161 results)
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[Journal Article] Biodistribution of water-soluble Carbon Nanotubes in mice and its biocompatibility2012
Author(s)
S.Abe, S.Itoh, D.Hayashi, T.Kobayashi, T.i Kiba, T.Akasaka, M.Uo, Y.Yawaka, S.Sato, F.Watari, T.Takada
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Journal Title
J.Nanoscience and Nanotechnology
Volume: 12
Issue: 1
Pages: 700-706
DOI
Related Report
Peer Reviewed
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[Journal Article] Interaction between titanium and phosphoproteins revealed by chromatography column packed woth titanium beads2012
Author(s)
Y.Kuboki, T.Furutake, M.Sato, Y.Sun, H.Unuma, R.Fujisawa, S.Abe, T.Akasaka, F.Watari, H.Takita, R.Sammons
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Journal Title
Bio-Medical Materials and Engineering
Volume: (accepted)
Related Report
Peer Reviewed
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[Journal Article] Internal Distribution of Micro-/Nano-sized Inorganic Particles and their Cytocompatibility2011
Author(s)
S. Abe, N. Iwadera, M. Esaki, I. Kida, M. Mutoh, T. Akasaka, M. Uo, Y. Yawaka, M. Morita, K. Haneda, T. Yonezawa, and F. Watari
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Journal Title
Material Science and Engineering
Volume: 18
Pages: 19201301-3
Related Report
Peer Reviewed
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[Journal Article] Observation of 3D network nano-structure of Carbon Nanotubes Scaffold for cultivation2011
Author(s)
S. Abe, K. Ishikawa, A. Hyono, H. Kobayashi, T. Kiba, T. Akasaka, M. Uo, Y. Yawaka, S. Sato, T. Yonezwa, and F. Watari
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Journal Title
J. Surface Science and Nanotechnology
Volume: 9
Pages: 80-84
NAID
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Peer Reviewed
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[Journal Article] Observation of 3D network nano-structure of Carbon Nanotubes Scaffold for cultivation2011
Author(s)
S.Abe, K.Ishikawa, A.Hyono, H.Kobayashi, T.Kiba, T.Akasaka, M.Uo, Y.Yawaka, S.Sato, T.Yonezwa, F.Watari
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Journal Title
J.Surface Science and Nanotechnology
Volume: 9
Pages: 80-84
NAID
Related Report
Peer Reviewed
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[Journal Article] Biodistribution of water-soluble Carbon Nanotubes in mice and its biocompatibility2011
Author(s)
Shigeaki Abe, Sachiko Itoh, Daisuke Hayashi, Toshihisa Kobayashi, Takayuki Kiba, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Shin-Ichiro Sato, Fumio Watari, Tomoya Takada
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Journal Title
J.Nanoscience and Nanotechnology
Volume: (in press)
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Peer Reviewed
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[Journal Article] Internal Distribution of Micro-/Nano-sized Inorganic Particles and their Cytocompatibility2011
Author(s)
Shigeaki Abe, Nobuki Iwadera, Mitsue Esaki, Ikuhiro Kida, Mami Mutoh, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Manabu Morita, Koichi Haneda, Tetsu Yonezawa, Fumio Watari
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Journal Title
Material Science and Engineering
Volume: 49(in press)
Related Report
Peer Reviewed
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[Journal Article] Internal distribution of micro-/nano-sized ceramics and metals particles in mice2010
Author(s)
S. Abe, I. Kida, M. Esaki, N. Iwadera, M. Mutoh, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, M. Morita, Y. Sato, K. Haneda, T. Yonezawa, B. Jeyadevan, K. Tohji, and F. Watari
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Journal Title
J. Ceramic Society of Japan
Volume: 118
Pages: 525-529
NAID
Related Report
Peer Reviewed
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[Journal Article] Internal distribution of micro-/nano-sized ceramics and metals particles in mice2010
Author(s)
Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Nobuki Iwadera, Mami Mutoh, Chika Koyama, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Manabu Morita, Yoshinori Sato, Koichi Haneda, Tetsu Yonezawa, Balachandran Jeyadevan, Kazuyuki Tohji, Fumio Watari
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Journal Title
J.Ceramic Society of Japan
Volume: 118
Pages: 525-529
NAID
Related Report
Peer Reviewed
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[Journal Article] Photophysical characterization of coumarin-doped poly (lactic acid) microparticles and visualization of the biodistribution2010
Author(s)
Shigeaki Abe, Takayuki Kiba, Kiyotada Hosokawa, Satoru Nitobe, Takashi Hirota, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Shin-Ichiro Sato, Fumio Watari, Iosif D.Rosca
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Journal Title
J.Electron Spectroscopy and Related Phenomena
Volume: 181
Pages: 181-185
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[Journal Article] Internal distribution of micro-/nano-sized ceramics and metals particles in mice2010
Author(s)
Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Nobuki Iwadera, Mami Mutoh, Chika Koyama, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Manabu Morita, Yoshinori Sato, Koichi Haneda, Tetsu Yonezawa, Balachan dran Jeyadevan, Kazuyuki Tohji, Fumio Watari
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Journal Title
J.Ceramic Society of Japan (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Photophysical characterization of coumarin-doped poly(lactic acid)microparticles and visualization of the biodistribution2010
Author(s)
Shigeaki Abe, Takayuki Kiba, Kiyotada Hosokawa, Satoru Nitobe, Takashi Hirota, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Shin-Ichiro Sato, Fumio Watari, Iosif D.Rosca
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Journal Title
J.Electron Spectroscopy and Related Phenomena (in press)
Related Report
Peer Reviewed
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[Journal Article] Biodistribution imaging of magnetic nanoparticles in mice compared with X-ray scanning analytical microscopy and Magnetic Resonance imaging2009
Author(s)
S. Abe, I. Kida, M. Esaki, T. Akasaka, M. Uo, Y. Sato, B. Jeyadevan, Y. Kuboki, M. Morita, K. Tohji, and F. Watari
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Journal Title
Bio-Medical Materials and Engineering
Volume: 19
Pages: 213-220
Related Report
Peer Reviewed
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[Journal Article] Biodistribution imaging of magnetic nanoparticles in mice compared with X-ray scanning analytical microscopy and Magnetic Resonance imaging2009
Author(s)
Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Yoshinori Sato, Balachandran Jeyadevan, Yoshinori Kuboki, Manabu Morita, Kazuyuki Tohji, Fumio Watari
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Journal Title
Bio-Medical Materials and Engineering 19
Pages: 213-220
Related Report
Peer Reviewed
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[Journal Article] Visualization of invasion into the body and internal diffusion of nanoparticles2009
Author(s)
Fumio Watari, Shigeaki Abe, Iosif.D.Rosca, Atsuro Yokoyama, Motohiro Uo, Tsukasa Akasaka, Noriyuki. Takashi, Yasunori Totsuka, Eri.Hirata, Makoto Matsuoka, Kosuke. Ishikawa, Sachiko. Itoh, Yasutaka. Yawaka
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Journal Title
Key Engineering Materials 396-398
Pages: 569-572
Related Report
Peer Reviewed
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[Journal Article] Material nanosizing effect on living organisms : non-specific, biointeractive, physical size effects2009
Author(s)
Fumio Watari, Noriyuki Takashi, Atsuro Yokoyama, Motohiro Uo, Tsukasa Akasaka, Yoshinori Sato, Shigeaki Abe, Yoshinori Totsuka, Kazuyuki Tohji
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Journal Title
J.Royal Society Interface 6
Related Report
Peer Reviewed
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[Journal Article] Physical properties of alminosilicate nanotubes, Imogolite, as scaffold and effect on osteoblastic mineralization2009
Author(s)
Kosuke Ishikawa, Tsukasa Akasaka, Yoshinobu Nodasaka, Natsumi Ushijima, Masayuki Kaga, Shigeaki Abe, Motohiro Uo, Yasutaka Yawaka, Masaya Suzuki, Fumio Watari
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Journal Title
Nano Biomedicine 9
Pages: 109-120
Related Report
Peer Reviewed
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[Presentation] 3D structure observation of nanomaterial scaffolds for tissue engineering using electron and atomic force microscope2010
Author(s)
S. Abe, H. Kobayashi, T. Kiba, K. Ishikawa, M. Mutoh, T. Akasaka, M. Uo, Y. Yawaka, S. Sato, F. Watari, M. Suzuki
Organizer
6th International Workshop on Nano-scale Spectroscopy and Nanotechnnology
Place of Presentation
Kobe
Year and Date
2010-10-26
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[Presentation] 3D structure of nanomaterial scaffolds for tissue engineering using electron and atomic force microscope2010
Author(s)
Shigeaki Abe, Hirohisa Kobayashi, Takayuki Kiba, Kosuke Ishikawa, Mami Mutoh, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Shin-Ichiro, Fumio Watari, Masaya Suzuki
Organizer
The 6^<th> International Workshop on Nanoscale Spectroscopy and Nanotechnology
Place of Presentation
神戸大学、兵庫県
Related Report
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[Presentation] Internal distribution of micro-/nano-sized inorganic particles and its cytocoxisity2010
Author(s)
Shigeaki Abe, Nobuki Iwadera, Kosuke Ishikawa, Atsushi Hyono, Sachiko Itoh, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Yoshinori Kuboki, Tetsu Yonezawa, Fumio Watari
Organizer
3^<rd> International Conference of Ceramics 2010
Place of Presentation
グランキューブ大阪、大阪府
Related Report
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[Presentation] Internal distribution of several nano-magnetic particles in mice2009
Author(s)
S. Abe, I. Kida, M. Esaki, T. Akasaka, M. Uo, Y. Kuboki, M. Morita, K. Haneda, B. Jeyadevan, Y. Sato, K. Tohji, F. Watari
Organizer
9th Asian BioCeramics Symposium
Place of Presentation
Nagoya
Year and Date
2009-12-09
Related Report
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[Presentation] Internal distribution of several nano-magnetic particles in mice2009
Author(s)
Shigeaki Abe, Ikuhiro Kida, M.Esaki, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Manabu Morita, Koichi Haneda, Balachandran Jeyadevan, Yoshinori Sato, Kazuyuki Tohji, Fumio Watari
Organizer
9^<th> Asian BioCeramics Symposium(ABC2009)
Place of Presentation
Nagoya Congress Center, Nagoya
Year and Date
2009-12-09
Related Report
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[Presentation] Observation of internal distribution of micro/nano-sized ceramics and metals particles in mice2009
Author(s)
S. Abe, N. Iwadera, M. Mutoh, C. Koyama, M. Esaki, T. Akasaka, M. Uo, M. Morita, Y. Kuboki, K. Haneda, Ya. Yawaka, F. Uchida, T. Yonezawa, F. Watari
Organizer
22nd International Symposium on Ceramics in Medicine
Place of Presentation
Daegu
Year and Date
2009-10-28
Related Report
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[Presentation] Observation of internal distribution of micro/nano-sized ceramics and metals particles in mice2009
Author(s)
Shigeaki Abe, Nobuki Iwadera, Mami Mutoh, Chika Koyama, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Manabu Morita, Yoshinori Kuboki, Koichi Haneda, Yasutaka Yawaka, Fumio Uchida, Tetsu Yonezawa, Fumio Watari
Organizer
22^<nd> International Symposium on Ceramics in Medicine(Bioceramics22)
Place of Presentation
Daegu(South Korea)
Year and Date
2009-10-28
Related Report
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[Presentation] Photophysical characterization of cumarin doped poly(lactic acid) micro particles and its fabrication for bioimaging2009
Author(s)
S. Abe, I. Rosca, T. Kiba, K. Hosokawa, H. Kobayashi, S. Nitobe, T. Hirota, T. Akasaka, M. Uo, Y. Kuboki, S. Sato, F. Watari
Organizer
11th International Conference on Electronic Spectroscopy and Surface
Place of Presentation
Nara
Year and Date
2009-10-06
Related Report
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[Presentation] A Photophysical characterization of cumarin doped poly(lactic acid)micro particles and its fabrication for bioimaging2009
Author(s)
Shigeaki Abe, Iosif D.Rosca, Takayuki Kiba, Kiyotada Hosokawa, Hirohisa Kobayashi, Satoru Nitobe, Takashi Hirota, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Shin-Ichiro Sato, Fumio Watari
Organizer
11^<th> International Conference on Electronic Spectroscopy and Surface
Place of Presentation
Nara Prefectural New Public Hall, Nara
Year and Date
2009-10-06
Related Report
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