The application of periodontal ligament stem cells for the injured neural tissues
| Project/Area Number |
21791942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TOMOKIYO Atsushi Kyushu University, 歯学研究院・歯科保存学研究分野, 助教 (20507777)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯学 / 移植・再生医療 / 細胞・組織 / 脳・神経 / 歯根膜 / 幹細胞 / 神経再生 / NGF / Microarray / 二次元電気泳動 / 神経細胞分化 / 細胞遊走 / アポトーシス |
|---|
| Research Abstract |
We recently developed a multipotent clonal human periodontal ligament (PDL) cell line, termed cell line 1-17. To clarify the effects of PDL stem cells on neural regeneration remain unclear, we investigated the effects of cell line 1-17 on neurocytic differentiation, migration, and survival of PC12 cells. Cell line 1-17 induced neurocytic differentiation and migration of PC12 cells. Furthermore, this line exerted antiapoptotic effects on differentiated PC12 cells. Thus, PDL stem cells may play a role in peripheral nerve innervation during its regeneration.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2008.2009
Author(s)
Hashiguchi I, Yoshimine Y, Maeda H, Gotou Y, Fujii S, Tomokiyo A, Yoshida K, Nishigaki S, Monnouch S, Hori K, Okumura H, Akamine A.
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Journal Title
Fukuoka Igaku Zasshi. 100(5)
Pages: 111-117
NAID
Related Report
Peer Reviewed
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[Journal Article] An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2008.2009
Author(s)
Hashiguchi I, Yoshimine Y, Maeda H, Gotou Y, Fujii S, Tomokiyo A, Yoshida K, Nishigaki S, Monnouch S, Hori K, Okumura H, Akamine A.
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Journal Title
Fukuoka Igaku Zasshi 100(5)
Pages: 111-117
NAID
Related Report
Peer Reviewed
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