| Project/Area Number |
21791942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TOMOKIYO Atsushi Kyushu University, 歯学研究院・歯科保存学研究分野, 助教 (20507777)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯学 / 移植・再生医療 / 細胞・組織 / 脳・神経 / 歯根膜 / 幹細胞 / 神経再生 / NGF / Microarray / 二次元電気泳動 / 神経細胞分化 / 細胞遊走 / アポトーシス |
|---|
| Research Abstract |
We recently developed a multipotent clonal human periodontal ligament (PDL) cell line, termed cell line 1-17. To clarify the effects of PDL stem cells on neural regeneration remain unclear, we investigated the effects of cell line 1-17 on neurocytic differentiation, migration, and survival of PC12 cells. Cell line 1-17 induced neurocytic differentiation and migration of PC12 cells. Furthermore, this line exerted antiapoptotic effects on differentiated PC12 cells. Thus, PDL stem cells may play a role in peripheral nerve innervation during its regeneration.
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