Suppressive effect of invasion and metastasis of oral squamous cell carcinoma by maspin expression
| Project/Area Number |
21791982
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Maspin / がん浸潤様式 / uPA / uPAR / 口腔扁平上皮癌 / 細胞外マトリックス / 浸潤様式 / 浸潤 / プロテアーゼ |
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| Research Abstract |
Maspin expression in oral squamous cell carcinoma(OSCC) was detected in 64.8%. Patients with positive maspin expression had a significantly better prognosis. In contrast, maspin expression was lower in mode of invasion(Yamamoto-Kohama Critria) 4D type with high invasive potential. Moreover, Maspin expression showed a negative correlation with uPA/uPAR expression in the uPA/uPAR system. Expression pattern, uPA(+)/uPAR(+)/Maspin(-), exhibited a stronger invasive potential and the worst survival rate than other invasive grades of OSCC.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma2009
Author(s)
Ohara T, Kawashiri S, Tanaka A, Noguchi N, Kitahara H, Okamune A, Kato K, Hase T, Nakaya H, Yoshizawa K
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Journal Title
Pathol Oncol Res
Volume: 15
Issue: 3
Pages: 429-36
DOI
Related Report
Peer Reviewed
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