An alternative treatment for osteoporosis with DHNA.
| Project/Area Number |
21791995
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MURAKAMI Jun 岡山大学, 岡山大学病院, 助教 (40362983)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨粗鬆症 / DHNA / 臨床 / 薬理学 / 遺伝子 / 発現制御 |
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| Research Abstract |
The aim of this study is to confirm the antiosteoporotic effect of DHNA in ovariectomized(OVX) mice. This study used female ICR OVX mice and female ICR sham operated mice. OVX mice were randomized into four groups : DHNA group, Vitamine K2(VK) group, Risedronate(Ris) group and control group. Histological and radiographical analysis showed that in the OVX group, the travecular bone was narrow and the bone marrow cavity was wide. On the other hand, these osteoporotic changes were improved in DHNA and Ris group. DHNA had some effects for improving bone mass reduction caused by osteoporosis and may become an alternative medicine for osteoporosis.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption.2009
Author(s)
Matsubara M, Yamachika E, Tsujigiwa H, Mizukawa N, Ueno T, Murakami J, Ishida N, Kaneda Y, Shirasu N, Takagi S.
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Journal Title
Osteoporos Int. (in press)
Related Report
Peer Reviewed
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