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An alternative treatment for osteoporosis with DHNA.

Research Project

Project/Area Number 21791995
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

MURAKAMI Jun  岡山大学, 岡山大学病院, 助教 (40362983)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨粗鬆症 / DHNA / 臨床 / 薬理学 / 遺伝子 / 発現制御
Research Abstract

The aim of this study is to confirm the antiosteoporotic effect of DHNA in ovariectomized(OVX) mice. This study used female ICR OVX mice and female ICR sham operated mice. OVX mice were randomized into four groups : DHNA group, Vitamine K2(VK) group, Risedronate(Ris) group and control group. Histological and radiographical analysis showed that in the OVX group, the travecular bone was narrow and the bone marrow cavity was wide. On the other hand, these osteoporotic changes were improved in DHNA and Ris group. DHNA had some effects for improving bone mass reduction caused by osteoporosis and may become an alternative medicine for osteoporosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (4 results)

  • [Journal Article] Suppressive effects of 1, 4-dihydroxy-2-naphthoic acid administration on bone resorption2010

    • Author(s)
      Matsubara M, Murakami J, et al
    • Journal Title

      Osteoporos Int

      Volume: 21(8) Pages: 1434-47

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro experimental study of the relationship between the apparent diffusion and changes in cellularity and cell morphology2009

    • Author(s)
      Matsumoto Y, Murakami J, et al
    • Journal Title

      Oncol Rep

      Volume: 22(3) Pages: 641-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption.2009

    • Author(s)
      Matsubara M, Yamachika E, Tsujigiwa H, Mizukawa N, Ueno T, Murakami J, Ishida N, Kaneda Y, Shirasu N, Takagi S.
    • Journal Title

      Osteoporos Int. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology.2009

    • Author(s)
      Matsumoto YM, et al.
    • Journal Title

      Oncol Rep. 22

      Pages: 641648-641648

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging.2009

    • Author(s)
      Matsuya R, et al.
    • Journal Title

      Int J Oncol. 35

      Pages: 893900-893900

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] An alternative treatment for ostoeporosis with DHNA-microCT analysis2011

    • Author(s)
      Kita K, Murakami J, et al
    • Organizer
      18th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      広島国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] An alternative treatment for ostoeporosis with DHNA-microCT analysis2011

    • Author(s)
      Kita K, Murakami J, et al
    • Organizer
      Int.Congress of DentoMaxilloFacial Radiology
    • Place of Presentation
      広島国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vitro条件下において細胞外基質を賛成する象牙芽幹細胞株の樹立に関する研究2010

    • Author(s)
      村上純, 畝坪輝寿, 芦田昌和, 片嶋和典, 藤田麻里子, 本多康聡, 柳文修, 浅海淳一
    • Organizer
      第51回日本歯科放射線学会総会
    • Place of Presentation
      鶴見大学記念館
    • Related Report
      2011 Final Research Report
  • [Presentation] 1, 4-dihydroxy-2-naphthoicacid(DHNA)による骨吸収抑制作用について2009

    • Author(s)
      村上純, 畝坪輝寿, 松崎秀信, 柳文修, 浅海淳一
    • Organizer
      第50回日本歯科放射線学会総会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 1,4-dihydroxy-2-naphthoic acid(DHNA)投与による骨吸収抑制作用について2009

    • Author(s)
      村上純
    • Organizer
      第50回日本歯科放射線学会総会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)
    • Related Report
      2009 Annual Research Report
  • [Book] Encyclopedia of DNA research2011

    • Author(s)
      Jun Murakami, et al
    • Publisher
      Nova science publishers, Inc
    • Related Report
      2011 Final Research Report
  • [Book] Drug resistant neoplasms2009

    • Author(s)
      Jun Murakami, et al
    • Publisher
      Nova science publishers, Inc
    • Related Report
      2011 Final Research Report
  • [Book] Bacterial DNA, DNA polymerase and DNA helicases2009

    • Author(s)
      Jun Murakami, et al
    • Publisher
      Nova science publishers, Inc
    • Related Report
      2011 Final Research Report
  • [Book] Bacterial DNA, DNA polymerase and DNA helicases2009

    • Author(s)
      Jun Murakami
    • Publisher
      Nova Science Publishers, Inc(in press)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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