Establishment of the method for oral tissue construction using gap junctional communication.

• Project/Area Number: 21792054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: YAMADA Aya Tohoku University, 大学院・歯学研究科, 助教 (40295085)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: エナメル質再生 / 細胞間結合 / Gja1

Research Abstract

Gja1 regulates ameloblastin expression in dental epithelium. We have reported that ERK1/2 phosphorylation induced by TGF-β1 regulates expression of ameloblastin via gap junctional intercellular communication.
The results of this study indicated that gap junctional communication regulates intracellular signaling. And these regulatory mechanisms are important to understand the role of gap junctional comunication not only in tooth morphogenesis but also in another organs morphogenesis.

Research Products

• [Journal Article] Expressions and Functions of Neurotrophic Factors in Tooth Development. (2011)
  • Author(s): 岩本勉, 山田亜矢, Arakaki M., Sugawara Y.,Ono M., Futagi M., Yoshizaki K., Fukumoto E., 中村卓史, 福本敏
  • Journal Title: Journal of Oral BioscienceJournal Biosciences 53(1) Pages: 13-21
  • NAID: 10027793552
  • Peer Reviewed
• [Journal Article] Expression and Functions of Neurotrophic Factors in Tooth Development. (2011)
  • Author(s): Tsutomu Iwamoto, Aya Yamada, Makiko Arakaki, Yu Sugawara, Mariko Ono, Masaharu Futaki, Keigo Yoshizaki, Emiko Fukumoto, Takashi Nakamura, Satoshi Fukumoto
  • Journal Title: Journal of Oral Biosciences Volume: 53(1) Pages: 13-21
  • NAID: 10027793552
  • Peer Reviewed
• [Journal Article] エナメル芽細胞の分化制御機構 (2010)
  • Author(s): 山田亜矢、岩本勉、中村卓史、福本敏
  • Journal Title: 小児歯科学雑誌 48巻3号 Pages: 374-380
  • NAID: 10027489970
  • Peer Reviewed
• [Journal Article] PDGFs regulate tooth germ proliferation and ameloblast deifferentiation. (2010)
  • Author(s): Wu Nan, 岩本勉, Sugawara Y., Futagi M., Yoshizaki K., Yamamoto S., 山田亜矢, 中村卓史, Nonaka K., 福本敏
  • Journal Title: Archives of Oral Biology 55(6) Pages: 426-434
  • Peer Reviewed
• [Journal Article] エナメル芽細胞の分化制御機構 (2010)
  • Author(s): 山田亜矢, 岩本勉, 中村卓史, 福本敏
  • Journal Title: 小児歯科学雑誌 Volume: 48(1) Pages: 374-380
  • NAID: 10027489970
  • Peer Reviewed
• [Journal Article] PDGFs regulate tooth germ proliferation and ameloblast deifferentiation. (2010)
  • Author(s): Wu Nan, Tsutomu Iwamoto, Yu Sugawara, Masaharu Futaki, Keigo Yoshizaki, Shinya Yamamoto, Aya Yamada, Takashi Nakamura, Kazuaki Nonaka, Satoshi Fukumoto
  • Journal Title: Archives of Oral Biology Volume: 55(6) Pages: 426-434
  • Peer Reviewed
• [Journal Article] Influences of Interferon-gamma on Cell Proliferation and Interleukin-6 Production in Down Syndrome derived Fibroblasts (2009)
  • Author(s): Tsutomu Iwamoto, Aya Yamada, Kenji Yuasa, Emiko Fukumoto, Takashi Nakamura, Taku Fujiwara, Satoshi Fukumoto
  • Journal Title: Archives of Oral Biology 54 Pages: 963-969
  • Peer Reviewed
• [Journal Article] Critical Role of Heparin Binding Domains of Ameloblastoma Proliferation (2009)
  • Author(s): Akira Sonoda, Tsutomu Iwamoto, Takashi Nakamura, Emiko Fukumoto, Keigo Toshizaki, Aya Yamada, Makiko Arakaki, Hidemitsu Harada, Kazuaki Nonaka, Seiji Nakamura, Yoshihiko Yamada, Satoshi Fukumoto
  • Journal Title: The Journal of Biological Chemistry 284(40) Pages: 27176-27184
  • Peer Reviewed
• [Presentation] 象牙芽細胞分化におけるギャップ結合分子の発現および機能解析 (2010)
  • Author(s): 岩本勉、中村卓史、吉崎恵悟、山田亜矢、福本敏
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 船堀
  • Year and Date: 2010-09-22
• [Presentation] GSK-3 β inhibitor promotes reprogramming of dental pulp cell. (2010)
  • Author(s): Yamada A., Nakamura T., Iwamoto T., Fukumoto S.
  • Organizer: The 88^<th> General Session & Exihibition of the IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] The role of Gjal on salivary gland branching morphogenesis. (2010)
  • Author(s): Suzuki H., Yamada A., Iwamoto T., Nakamura T., Fukumoto S.
  • Organizer: The 88^<th> General Session & Exihibition of the IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] GSK-3β inhibitor promotes reprogramming of dental pulp cell. (2010)
  • Author(s): Aya Yamada, Takashi Nakamura, Tsutomu Iwamoto, Satoshi Fukumoto
  • Organizer: The 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] 唾液腺分岐におけるギャップ結合の役割解明と再生への応用 (2010)
  • Author(s): 鈴木宏治、山田亜矢、岩本勉、中村卓史、福本敏
  • Organizer: 第48回日本小児歯科学会大会(優秀発表賞受賞)
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-05-19
• [Presentation] Pannexin 3, a gap junction protein, regulates odontoblasts differentiation. (2010)
  • Author(s): Iwamoto T., Nakamura T., Yamada A., Yamada.Y., Fukumoto S.
  • Organizer: Experimental Biology2010
  • Place of Presentation: Anaheim, U.S.A
  • Year and Date: 2010-04-26
• [Presentation] Regulation of ameloblastin expression via gap junctional communication. (2010)
  • Author(s): Yamada A., Iwamoto T., Nakamura T., Fukumoto S.
  • Organizer: Experimental Biology2010
  • Place of Presentation: Anaheim, U.S.A
  • Year and Date: 2010-04-26
• [Presentation] Regulation of ameloblastin expression via gap functional communication. (2010)
  • Author(s): Aya Yamada, Tsutomu Iwamoto, Takashi Nakamura, Satoshi Fukumoto
  • Organizer: Experimental Biology
  • Place of Presentation: Anaheim, U.S.A
  • Year and Date: 2010-04-26
• [Presentation] 細胞間結合を利用したエナメル芽細胞の分化制御法の開発 (2009)
  • Author(s): 山田亜矢, 他4名
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台市
  • Year and Date: 2009-06-16
• [Presentation] エナメル芽細胞分化過程における細胞間結合の役割 (2009)
  • Author(s): 山田亜矢, 他6名
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟市
• [Presentation] Intracellular calcium regulates enamel matrix expression via gap junctional communication (2009)
  • Author(s): 山田亜矢, et al.
  • Organizer: 22^<th> Congress of the International Association of Paediatric Dentistry
  • Place of Presentation: Germany, Muncher
• [Remarks] ホームページ等