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Effect of liquid diet on purkinje cells in cerebellum

Research Project

Project/Area Number 21792062
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YABUSHITA Tadachika  Tokyo Medical and Dental University, 歯学部, 非常勤講師 (40420260)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords小脳 / 液状飼料 / 顎関節侵害受容器 / 閉口筋筋紡錘 / 電気生理 / フィードバック / 軟食化 / 学習 / 咀嚼運動 / 長期抑圧
Research Abstract

Recently, it has been shown that prolonged feeding on liquid diet after being weaned impedes functional development and leads to immature mastication in growing rats. Since jaw muscle spindles play an important role in the control of jaw movements during normal masticatory function, in this study we investigated the effect of prolonged feeding on liquid diet after being weaned on the functional development of jaw-closing muscle spindles in growing rats. Soon after weaning, 40 female Wistar rats were divided into two equal groups. The control group fed on solid diet and the experimental group fed on liquid diet. At 5, 7, 9 and 11 weeks, the rats were anesthetized and the response of the masseter muscle spindles to ramp-and-hold jaw stretches were recorded from the mesencephalic trigeminal nucleus. In the experimental groups, both the dynamic and the static indices were significantly lower than those of the control groups at the age of 5, 7, 9 and 11 weeks old. There was no significant change within the same group during the experimental period in both indices. These results suggest that long-term masticatory functional change due to liquid diet feeding may impede maturation of the functional properties of jaw-closing muscle spindles, leading to immature mastication in growing rats.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats2011

    • Author(s)
      Naito S, Ishida T, Kokai S, Fujita K、Shibata M、Yabushita T,
    • Journal Title

      The Angle Orthodontist (in print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats2011

    • Author(s)
      Naito S, Ishida T, Kokai S, Fujita K, Shibata M, Yabushita T, Ono T
    • Journal Title

      The Angle Orthodontist

      Volume: (in print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 液状飼料飼育が成長期ラットの閉口筋筋紡錘に与える影響2010

    • Author(s)
      柴田真衣
    • Journal Title

      口腔病学会誌 77巻

      Pages: 53-58

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 液状飼料飼育が成長期ラットの閉口筋筋紡錘に与える影響2010

    • Author(s)
      柴田真衣
    • Journal Title

      口腔病学会誌

      Volume: 77 Pages: 53-58

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 咬合高径増加に対するラット顎関節機械受容器の機能適応について2010

    • Author(s)
      内藤聡美、石田宝義、小海暁、藤田紘一、柴田真衣、藪下忠親、小野卓史
    • Organizer
      第75回口腔病学術大会
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 咬合高径増加に対するラット顎関節機械受容器の機能適応について2010

    • Author(s)
      内藤聡美、石田宝義、小海暁、藤田紘一、柴田真衣、藪下忠親, 小野卓史
    • Organizer
      第75回口腔病学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effective Strategy in Treating Saddle-Shaped Arch2010

    • Author(s)
      Tadachika Yabushita
    • Organizer
      World Federation of Orthodontists
    • Place of Presentation
      Sydney
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 液状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について2010

    • Author(s)
      平沼摩耶, 小海暁, 藪下忠親, 小野卓史
    • Organizer
      液状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of liquid diet feeding after being weaned on the properties of jaw-closing muscle spindles2010

    • Author(s)
      Shibata M, Fujita K, Ishida T, Yabushita T
    • Organizer
      7th International Orthodontic Congress
    • Related Report
      2010 Final Research Report
  • [Presentation] 状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について2010

    • Author(s)
      平沼摩耶, 小海暁, 藪下忠親, 小野卓史
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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