Detection of new ion channel in the nerve terminals of the periodontal ligament

• Project/Area Number: 21792064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Niigata University
• Principal Investigator: HARADA Fumiko Niigata University, 医歯学系, 特任助教 (00397150)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 歯学 / 神経科学 / イオンチャネル / ASIC3 / ルフィニ神経終末 / 歯根膜 / 三叉神経節 / 機械受容器 / 機械感覚 / 歯根膜神経終末 / 機械受容

Research Abstract

The acid-sensing ion channel 3 (ASIC3) has been reported to participate in acid sensing, mechanosensation, and nociception. The present study examined the expression of ASIC3 in the lingual periodontal ligament of mouse incisors by immunohistochemistry. Furthermore, the expression of ASIC3 in the trigeminal ganglion-which innervates the periodontal ligament-was investigated at protein and mRNA levels. These findings suggest that ASIC3 functions as a molecule for mechanosensation in the periodontal Ruffini endings.

Research Products

• [Journal Article] Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors. (2011)
  • Author(s): Rahman F, Harada F, Saito I, Suzuki A, Kawano Y, Izumi K, Nozawa-Inoue K, Maeda T.
  • Journal Title: Neurosci Lett. 488(2) Pages: 173-177
  • Peer Reviewed
• [Journal Article] Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors. (2011)
  • Author(s): Rahman F, Harada F, Saito I, Suzuki A, Kawano Y, Izumi K, Nozawa-Inoue K, Maeda T.
  • Journal Title: Neurosci Lett. Volume: 488(2) Pages: 1723-177
  • Peer Reviewed
• [Journal Article] GDNF expression in terminal schwann cells associated with the periodontal Ruffini endings of the rat incisors during nerve regeneration. (2009)
  • Author(s): Ohishi M, Harada F, et al.
  • Journal Title: Anatomical Record 292 Pages: 1185-1191
  • Peer Reviewed
• [Presentation] Multiple neurotrophins involve regeneration of the periodontal Ruffini endings after transection of rat inferior alveolar nerve. (2010)
  • Author(s): Ohishi M, Harada F, Maeda T.
  • Organizer: Society for Neuroscience 40th annual meeting
  • Place of Presentation: San Diego,アメリカ合衆国
  • Year and Date: 2010-11-14
• [Presentation] Acid-Sensing Ion Channel 3 Expression in the Periodontal Ruffini Endings. (2010)
  • Author(s): Rahman F, Harada F, Kawano Y, Ohishi M, Nozawa-Inoue K, Saito I, Maeda T.
  • Organizer: IADR, 88th General Session & Exhibition
  • Place of Presentation: バルセロナ,スペイン
  • Year and Date: 2010-07-15
• [Presentation] Acid-Sensing Ion Channel 3 Expression in the Periodontal Ruffi ni Endings. (2010)
  • Author(s): Rahman F, Harada F, Kawano Y, Ohishi M, Nozawa-Inoue K, Saito I, Maeda T.
  • Organizer: 88th General Session & Exhibition of the International Association for Dental research
  • Place of Presentation: Barcelona.
• [Presentation] Multiple neurotrophins involve regeneration of the periodontal Ruffini endings after transection of rat inferior alveolar nerve. (2010)
  • Author(s): Ohishi M, Harada F, Maeda T.
  • Organizer: Society for Neuroscience 40th annual meeting
  • Place of Presentation: San Diego.
• [Presentation] Expression of ASIC3 in the Periodontal Ruffini Endings (2010)
  • Author(s): Farhana R, 原田史子, ほか4名
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手県民会館(盛岡市)