Effect of prolonged toothless condition hippocampal dentate gyrus cell proliferation
| Project/Area Number |
21792105
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ストレス / 海馬 / 歯状回 / 神経細胞 / 咬合不全 / 海場 / グルココルチコイドレセプター / 神経細胞新生 / 神経細胞死 |
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| Research Abstract |
To evaluate the mechanisms underlying serious impairment of hippocampal function as a result of prolonged toothless, we examined the effects of the early and late molarless conditions on cell proliferation in the hippocampal dentate gyrus(DG) of SAMP8 mice. A early molarless condition enhanced an age-related decline in learning ability in a water maze tset. A similar age dependent effect of early molarless condition was observed on the number of hippocampal cell proliferation. However, the effect of the late molarless condition was not significant. The results suggest that the prolonged molarless condition may enhance an age-related decline in cell proliferation in DG, thereby leading to serious deficits in learning ability.
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Report
(4 results)
Research Products
(9 results)
