| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
To evaluate the mechanisms underlying serious impairment of hippocampal function as a result of prolonged toothless, we examined the effects of the early and late molarless conditions on cell proliferation in the hippocampal dentate gyrus(DG) of SAMP8 mice. A early molarless condition enhanced an age-related decline in learning ability in a water maze tset. A similar age dependent effect of early molarless condition was observed on the number of hippocampal cell proliferation. However, the effect of the late molarless condition was not significant. The results suggest that the prolonged molarless condition may enhance an age-related decline in cell proliferation in DG, thereby leading to serious deficits in learning ability.
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