P.gingivalis target DC-SIGN to escape Th1-type immune response.

• Project/Area Number: 21792108
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Tohoku University
• Principal Investigator: TADA Hiroyuki Tohoku University, 病院, 医員 (70431632)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 免疫学 / 樹状細胞 / 細胞・組織 / サイトカイン / DC-SIGN

Research Abstract

Dendritic cells (DCs) express C-type lectin receptors (CLRs). Pathogenic bacteria subvert DC functions to escape immune surveillance by targeting the CLRs including DC-SIGN. In this study, we investigated the role played by Nod proteins in inducing the cross-priming of CD8^+T cells, and we demonstrate that Nod ligands significantly enhance the induction of DC-mediated cross-priming.

Research Products

• [Journal Article] Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells. (2011)
  • Author(s): Tada, H., Nemoto, E., Foster, B.L., Somerman, M.J., Shimauchi, H.
  • Journal Title: Bone. 48印刷中
  • Peer Reviewed
• [Journal Article] Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells (2011)
  • Author(s): Tada, H.
  • Journal Title: Bone Volume: (印刷中 未定)
  • Peer Reviewed
• [Journal Article] Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells. (2010)
  • Author(s): Tada, H., Nemoto, E., Kanaya, S., Hamaji, N., Sato, H., Shimauchi, H.
  • Journal Title: Biochem.Biophys.Res.Commun. 394 Pages: 1093-1097
  • Peer Reviewed
• [Journal Article] Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. (2010)
  • Author(s): Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y., Fujimoto, Y., Fukase, K., Suzuki, A., Mak, T.W., Ohteki, T.
  • Journal Title: J.Immunol. 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. (2010)
  • Author(s): Hasegawa, M., Osaka, T., Tawaratsumida, K., Yamazaki, T., Tada, H., Chen, G.Y., Tsuneda, S., Nunez, G., Inohara, N.
  • Journal Title: Infect.Immun. 78 Pages: 639-650
  • Peer Reviewed
• [Journal Article] Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells (2010)
  • Author(s): Tada, H.
  • Journal Title: Biochem.Biophys.Res.Commun. 394 Pages: 1093-1097
  • Peer Reviewed
• [Journal Article] Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo (2010)
  • Author(s): Asano, J.
  • Journal Title: J.Immunol. 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development (2010)
  • Author(s): Hasegawa, M.
  • Journal Title: Infect.Immun. 78 Pages: 639-650
  • Peer Reviewed
• [Presentation] 細胞外リン酸はPitおよびERK1/2を介してヒト歯髄細胞からBMP-2を誘導する (2010)
  • Author(s): 多田浩之、根本英二、島内英俊
  • Organizer: 第132回日本歯科保存学会春季学術大会(ポスター発表)
  • Place of Presentation: 熊本市
  • Year and Date: 2010-06-04
• [Presentation] 細胞外リン酸はPitおよびERK1/2を介してヒト歯髄細胞からBMP-2を誘導する (2010)
  • Author(s): 多田浩之
  • Organizer: 第132回日本歯科保存学会春季学術大会
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2010-06-04
• [Presentation] 細胞外リン酸によるヒト歯髄細胞からのbone morphogenetic protein-2発現誘導 (2009)
  • Author(s): 多田浩之、根本英二、金谷聡介、島内英俊
  • Organizer: 第131回日本歯科保存学会秋季学術大会(口頭発表)
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-30
• [Presentation] 細胞外リン酸によるヒト歯髄細胞からの bone morphogenetic protein-2発現誘導 (2009)
  • Author(s): 多田浩之
  • Organizer: 第131回日本歯科保存学会秋季学術大会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-30
• [Remarks] 日本歯科保存学会デンツプライ賞受賞平成22年10月28日