P.gingivalis target DC-SIGN to escape Th1-type immune response.
Project/Area Number |
21792108
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
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Research Institution | Tohoku University |
Principal Investigator |
TADA Hiroyuki Tohoku University, 病院, 医員 (70431632)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 免疫学 / 樹状細胞 / 細胞・組織 / サイトカイン / DC-SIGN |
Research Abstract |
Dendritic cells (DCs) express C-type lectin receptors (CLRs). Pathogenic bacteria subvert DC functions to escape immune surveillance by targeting the CLRs including DC-SIGN. In this study, we investigated the role played by Nod proteins in inducing the cross-priming of CD8^+T cells, and we demonstrate that Nod ligands significantly enhance the induction of DC-mediated cross-priming.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells.2010
Author(s)
Tada, H., Nemoto, E., Kanaya, S., Hamaji, N., Sato, H., Shimauchi, H.
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Journal Title
Biochem.Biophys.Res.Commun. 394
Pages: 1093-1097
Related Report
Peer Reviewed
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[Journal Article] Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.2010
Author(s)
Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y., Fujimoto, Y., Fukase, K., Suzuki, A., Mak, T.W., Ohteki, T.
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Journal Title
J.Immunol. 184
Pages: 736-745
Related Report
Peer Reviewed
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[Journal Article] Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.2010
Author(s)
Hasegawa, M., Osaka, T., Tawaratsumida, K., Yamazaki, T., Tada, H., Chen, G.Y., Tsuneda, S., Nunez, G., Inohara, N.
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Journal Title
Infect.Immun. 78
Pages: 639-650
Related Report
Peer Reviewed
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