The diagnosis of the risk of periodontitis: searching for the interleukin-6 receptor

• Project/Area Number: 21792114
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: KOMATSU Yasutaka Niigata University, 医歯学総合病院, 助教 (40422597)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 歯周炎 / IL-6 / IL-6レセプター / IL-6受容体

Research Abstract

Soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) are key molecules in regulation of IL-6 response. Multiple logistic regression analysis revealed significant association between genetic polymorphisms of IL-6R+48892 (A/C) and susceptibility to periodontitis. Moreover, cell surface expression of membrane-bound IL-6R in PBMC and lymphocyte was significantly higher in subjects who carry IL-6R+48892 A allele than that who did not carry. These results suggest that IL-6R gene polymorphisms could act as a risk factor for chronic periodontitis by regulating immunological cell surface expression of IL-6R and sIL-6R levels.

Research Products

• [Journal Article] Ef fects of irrigation with an antiseptic and oral administration o f a zithromycin o n bacteremia d ue to scaling an d ro ot planning. (2010)
  • Author(s): Morozumi T, Kubota T, Abe D, Shimizu T, Komatsu Y, Yo shie H
  • Journal Title: J Per iodontol 81 Pages: 1555-1563
  • Peer Reviewed
• [Journal Article] Serum cytokine and periodontal profiles in relation to d isease activity o f r heumatoid arthritis in Japanese adults. (2010)
  • Author(s): Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
  • Journal Title: J Periodontol 81 Pages: 650-657
  • Peer Reviewed
• [Journal Article] The effects of p eriodontal treatment o n s erum leptin, interleukin-6, and C-reactive protein. (2010)
  • Author(s): Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Noriko S, Yoshie H
  • Journal Title: J Per iodontol. 81 Pages: 1118-1123
  • Peer Reviewed
• [Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. (2009)
  • Author(s): Kobayashi T, M urasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H
  • Journal Title: J Periodontol 80 Pages: 792-799
  • Peer Reviewed
• [Journal Article] A ntibody responses t o periodontopathic bacteria in relation to rhe umatoid art hritis in Jap anese adults.
  • Author(s): Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H
  • Journal Title: J Periodontol in press
  • Peer Reviewed
• [Presentation] Genetic influence of serum interleukin-6 and its soluble receptor levels. (2010)
  • Author(s): Komatsu Y , K obayashi T, S himada Y,Yoshie H
  • Organizer: The 96th.Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology.
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-11-01
• [Presentation] Serum cytokine and periodontal profilesre lated to rheumatoid a rthritis activity. (2010)
  • Author(s): Kobayashi T , Murasawa A, Komatsu Y,Yokoyama T, Ishida K, Abe A, YamamotoK,Yoshie H
  • Organizer: The 96th.Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology.
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-11-01
• [Presentation] DNA methylation status of the interleukin-6 gene promoter in periodontitis. (2010)
  • Author(s): Ishida K, Ko bayashi T, Yo koyama T,Komatsu Y, Yoshie H
  • Organizer: The 96th.Annual Meeting of the American Academy of P eriodontology in collaboration with the Japanese Society of Periodontology.
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-11-01
• [Presentation] Genetic influence of senlm interleukin-6 and its soluble receptor levels (2010)
  • Author(s): 小松康高
  • Organizer: 第96回アメリカ歯周病学会共催日本歯周病学会2010年大会
  • Place of Presentation: ハワイコンベンションセンター(ハワイ・ホノルル)
  • Year and Date: 2010-11-01
• [Presentation] Er: YAG レーザーによるSRPの治癒効果および菌血症予防効果の検討 (2010)
  • Author(s): 小松康高、両角俊哉、小林哲夫、奥田一博、阿部大輔、吉江弘正
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松市
  • Year and Date: 2010-09-19
• [Presentation] 歯周炎および関節リウマチ患者におけるIL-6遺伝子プロモーター領域のメチル化解析 (2010)
  • Author(s): 石田光平、小林哲夫、小松康高、横山智子、岡田萌、吉江弘正
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松市
  • Year and Date: 2010-09-19