| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To investigate the relation between periodontitis and myocardial infarction, we have developed a sensing system for thrombus formation factors produced by periodontopathic bacterium. As a result, we observed increased plaque formation by macrophages in the presence of LPS. In addition, the plaque formation was decreased after infection with Aggregatibacter actinomycetemcomitans. We showed that foam cell formation in macrophages was significantly enhanced by stimulation of LDL.
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