Molecular mechanisms underlying dietary restriction-induced longevity
Project/Area Number |
21870014
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Kyoto University |
Principal Investigator |
HONJOH Sakiko Kyoto University, 生命科学研究科, 特定研究員 (30551379)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,808,000 (Direct Cost: ¥2,160,000、Indirect Cost: ¥648,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
|
Keywords | 老化 / 線虫 / 食餌制限 / 神経 |
Research Abstract |
We found that sensory organs play important roles in life span regulation in the nematode C. elegans. We previously reported that intermittent fasting (IF), a kind of dietary restriction, extends the life span of C. elegans by more than 60%. We found that mutant strains with various defects in sensory organ development responded to IF to a lesser extent than wild type animals. The results show that sensory perception mediates IF-induced longevity.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans2010
Author(s)
Okuyama, T., Inoue, H., Ookuma, S., Satoh, T., Kano, K., Honjoh, S., Hisamoto, N., Matsumoto, K., Nishid, E.
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Journal Title
Journal of biological chemistry Vol.285
Pages: 30274-30281
Related Report
Peer Reviewed
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[Journal Article] The ERK-MAPK pathway regulates longevity through SKN-1 and insuliIn-like signaling in Caenorhabditis elegans.2010
Author(s)
Okuyama, T., Inoue, H., Ookuma, S., Satoh, T., Kano, K., Honjoh, S., Hisamoto, N., Matsumoto, K., Nishid, E.
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Journal Title
Journal of biological chemistry
Volume: 285
Pages: 30274-30281
Related Report
Peer Reviewed
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