Biomechanical regulation of cell shape, proliferation and cell death

Research Project

Project/Area Number	21870040
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Morphology/Structure
Research Institution	National Institute of Genetics
Principal Investigator	HAYASHI Takashi National Institute of Genetics, 個体遺伝研究系, 助教 (50553765)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000) Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000) Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywords	発生 / 形態 / 成長 / 細胞死
Research Abstract	The roles of biomechanics on cell shape control, proliferation and cell death were studied using Drosophila melanogaster as the model system. It has been shown that the shape of cells is under the control of surface tension, which is produced by cytoskeletons, by studying the effects of manipulating the function of Rho, Rac or non-muscle Myosin in vivo. An experimental system for studying the roles of biomechanics on proliferation or cell death has also been established.