| Project/Area Number |
21890011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KANEHIRA Masahiko Tohoku University, 大学院・医学系・研究科, 非常勤講師 (90374941)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,509,000 (Direct Cost: ¥1,930,000、Indirect Cost: ¥579,000)
Fiscal Year 2010: ¥1,157,000 (Direct Cost: ¥890,000、Indirect Cost: ¥267,000)
Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000)
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| Keywords | 肺癌 / 癌幹細胞 / 骨髄由来間葉系幹細胞 / 癌 / 発生・分化 / 間葉系幹細胞 |
|---|
| Research Abstract |
Side population in A549 decreased by co-culturing with bone marrow-derived mesenchymal stem cell (BMMSCs). Moreover, expression levels Shh, BMP4 and Muc5AC in A549 were increased. These data suggest that BMMSCs would drive tumor stem cells in A549 toward differentiated. Moreover, production of Fgf10 was promoted in existence of A549, and neutralization of Fgf10 cancelled the SP decreasing effect of BMMSCs.
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