| Project/Area Number |
21890070
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Youji Tokyo Medical and Dental University, 医学部附属病院, 助教 (80323682)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
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| Keywords | 脳虚血 / 血栓溶解療法 / アネキシン2 / MRI / 脳梗塞 / 出血性合併症 / Magnetic resonance imaging / Arterial spin labeling / Dynamic susceptibility contrast |
|---|
| Research Abstract |
This study showed the efficacy of a novel combination therapy of recombinant annexin 2 and low dose tissue plasminogen activator (tPA) for acute ischemic stroke with employing MRI. The combination therapy could recanalize the occuluded cerebral artery in rat stroke, resulted in decreaseing the infarct volme model as well as the standard tPA therapy. Moreover, this therapy had less frequency of hemorrhagic complication than the standard rtPA therapy.
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