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A novel combination therapy of recombinant annexin 2 and low dose rtPA for acute ischemic stroke with employing MRI.

Research Project

Project/Area Number 21890070
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA Youji  Tokyo Medical and Dental University, 医学部附属病院, 助教 (80323682)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Keywords脳虚血 / 血栓溶解療法 / アネキシン2 / MRI / 脳梗塞 / 出血性合併症 / Magnetic resonance imaging / Arterial spin labeling / Dynamic susceptibility contrast
Research Abstract

This study showed the efficacy of a novel combination therapy of recombinant annexin 2 and low dose tissue plasminogen activator (tPA) for acute ischemic stroke with employing MRI. The combination therapy could recanalize the occuluded cerebral artery in rat stroke, resulted in decreaseing the infarct volme model as well as the standard tPA therapy. Moreover, this therapy had less frequency of hemorrhagic complication than the standard rtPA therapy.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] MRI reveals differential regulation of retinal and choroidal blood volumes in rat retina.2011

    • Author(s)
      Nair G, Tanaka Y, Kim M, Olson DE, Thule PM, Pardue MT, Duong TQ
    • Journal Title

      Neuroimage 54(2)(Epub 2010 Sep 17)

      Pages: 1063-1069

    • Related Report
      2010 Final Research Report
  • [Journal Article] Arterial spin labeling and dynamic susceptibility contrast CBF MRI in postischemic hyperperfusion, hypercapnia, and after mannitol injection2010

    • Author(s)
      Tanaka Y
    • Journal Title

      Journal of cerebral blood flow and metabolism

      Volume: Advance online publication Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial spin labeling and dynamic susceptibility contrast CBF MRI in postischemic hyperperfusion, hypercapnia, and after mannitol injection.

    • Author(s)
      Tanaka Y, Nagaoka T, Govind N, et al
    • Journal Title

      Journal of cerebral blood flow and metabolism. advance online publication (22 December 2010)

    • Related Report
      2010 Final Research Report
  • [Presentation] MRI灌流画像による脳血流測定の検討-hyperperfusionの定量性について-2011

    • Author(s)
      田中洋次
    • Organizer
      日本神経放射線学会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 経時的脳循環モニタとしてのArterial Spin Labeling (ASL) MRIの可能性-2010

    • Author(s)
      田中洋次
    • Organizer
      第16回日本脳神経モニタリング学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 経時的脳循環モニタとしてのArterial Spin Labeling(ASL)MRIの可能性2010

    • Author(s)
      田中洋次
    • Organizer
      第16回日本脳神経モニタリング学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] (シンポジウム)脳卒中の日常診療における脳循環画像。Dynamic susceptibility contrast MRI灌流画像(DSC-MRI)を用いた虚血性脳血管障害の診断2010

    • Author(s)
      田中洋次
    • Organizer
      日本脳脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] (シンポジウム)脳卒中の日常診療における脳循環画像。Dynamic susoeptibility contrast MRI.灌流画像(DSC-MRI)を用いた虚血性脳血管障害の診断2010

    • Author(s)
      田中洋次
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Arterial Spin Labeling MRI灌流画像による脳血流測定の検討-hyperperfusionの定量性について-2010

    • Author(s)
      田中洋次
    • Organizer
      日本脳神経CI学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-11
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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