Epigenetic mechanisms of antipsychotic drugs in glial cells
| Project/Area Number |
21890091
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MIYAKE Kunio University of Yamanashi, 医学工学総合研究部, 助教 (60550712)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,509,000 (Direct Cost: ¥1,930,000、Indirect Cost: ¥579,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
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| Keywords | 精神疾患 / 抗精神病薬 / エピジェネティクス / グリア細胞 / ヒストン脱アセチル化 / 抗炎症反応 / 神経科学 / DNAメチル化 / 脳・神経 / 薬理学 / ストレス / エピジェネティック |
|---|
| Research Abstract |
It has been suggested that glial cells are involved in pathological condition of mental disorder. However, the details of mechanism are still unknown. We showed here that treatment with an antipsychotic drug influences glial cell proliferation and changes the pattern of histone acetylation by coadministration of sodium butylate and inhibits the LPS-induced inflammatory response. These results can expect to lead to the development of new antipsychotic drugs as a target for glial cells.
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Report
(3 results)
Research Products
(11 results)
