Epigenetic mechanisms of antipsychotic drugs in glial cells

• Project/Area Number: 21890091
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: University of Yamanashi
• Principal Investigator: MIYAKE Kunio University of Yamanashi, 医学工学総合研究部, 助教 (60550712)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,509,000 (Direct Cost: ¥1,930,000、Indirect Cost: ¥579,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
• Keywords: 精神疾患 / 抗精神病薬 / エピジェネティクス / グリア細胞 / ヒストン脱アセチル化 / 抗炎症反応 / 神経科学 / DNAメチル化 / 脳・神経 / 薬理学 / ストレス / エピジェネティック

Research Abstract

It has been suggested that glial cells are involved in pathological condition of mental disorder. However, the details of mechanism are still unknown. We showed here that treatment with an antipsychotic drug influences glial cell proliferation and changes the pattern of histone acetylation by coadministration of sodium butylate and inhibits the LPS-induced inflammatory response. These results can expect to lead to the development of new antipsychotic drugs as a target for glial cells.

Research Products

• [Journal Article] Novel etiological and therapeutic strategies for neurodiseases : epigenetic understanding of gene-environment interactions. (2010)
  • Author(s): Kubota T, Miyake K, Hirasawa T, Nagai K, Koide T.
  • Journal Title: J Pharmacol Sci 113 Pages: 3-8
  • NAID: 10027744756
• [Journal Article] Novel etiological and therapeutic strategies for neurodiseases: epigenetic undertanding of gene-environment interactions (2010)
  • Author(s): Kubota T
  • Journal Title: J Pharmacol Sci Volume: 113 Pages: 3-8
• [Presentation] レット症候群責任蛋白質MeCP2の新規標的シナプス関連分子の同定 (2010)
  • Author(s): 三宅邦夫
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-12-08
• [Presentation] レット症候群責任蛋白質MeCP2の新規標的遺伝子の探索 (2010)
  • Author(s): 三宅邦夫
  • Organizer: 第4回日本エピジェネティクス研究会
  • Place of Presentation: 米子市文化ホール
  • Year and Date: 2010-05-28
• [Book] 精神疾患のエピジェネティクス:メチル化CpG結合蛋白(MeCP2)研究の最近の動向 (2011)
  • Author(s): 三宅邦夫、久保田健夫
  • Publisher: 先端医学社
• [Book] Epigenetics in autism and other neurodevelopmental diseases.Molecular Mechanism of Neurodegenerative diseases (2011)
  • Author(s): Miyake K, Hirasawa T, Koide T, Kubota T
  • Publisher: Landes Bioscince/Springer(in press)
• [Book] エピジェネティクス.増刊号:遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望 (2010)
  • Author(s): 三宅邦夫、久保田健夫
  • Publisher: 日本臨床
• [Book] 遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望 (2010)
  • Author(s): 三宅邦夫
  • Total Pages: 6
  • Publisher: 日本臨床
• [Remarks] ホームページ等
  • URL: http://www.epigenetmed.com/
• [Remarks]
  • URL: http://www.epignetmed.com/
• [Remarks]
  • URL: http://www.epigenetmed.com/