Abnormal connectivity in schizophrenia revealed by multi-modal MRI

• Project/Area Number: 21890119
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: MIYATA Jun Kyoto University, 大学院・医学研究科, 助教 (90549099)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 統合失調症 / MRI / 拡散テンソル画像 / connectivity / tract-based spatial statistics / surface-based analysis

Research Abstract

Abnormal connectivity in schizophrenia was investigated by means of the structural MRI and diffusion tensor imaging (DTI). In the analysis of gray matter using structural MRI, the association between cortical thickness and age in healthy people and schizophrenia was revealed. In the DTI analysis for white matter, normal cerebral white matter asymmetry was revealed to be reduced or exaggerated in schizophrenia. This abnormal asymmetry was also revealed to be the neural correlate of certain symptoms of schizophrenia.

Research Products

• [Journal Article] Age-related cortical thinning in schizophrenia. (2011)
  • Author(s): Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
  • Journal Title: Schizophrenia research 125 Pages: 21-29
  • NAID: 120002723136
  • Peer Reviewed
• [Journal Article] Age-related cortical thinning in schizophrenia (2011)
  • Author(s): Manabu Kubota
  • Journal Title: Schizophrenia Research Volume: 125 Pages: 21-29
  • Peer Reviewed
• [Journal Article] Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging.
  • Author(s): Miyata T, Sasamoto A, Koelkebeck K, Hirao K, Ueda K, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Hum Brain Mapp in press
  • Peer Reviewed
• [Journal Article] Abnormal Asymmetry of White Matter Integrity in Schizophrenia Revealed by Voxelwise Diffusion Tensor Imaging
  • Author(s): Jun Miyata
  • Journal Title: Human Brain Mapping Volume: (In press)(未定)
  • Peer Reviewed
• [Presentation] 統合失調症患者における白質統合性の低下と灰白質体積および厚さとの相関について (2011)
  • Author(s): 笹本彰彦, 宮田淳, 久保田学, 川田良作, 藤本心祐, 田中祐輔, 澤本仲克, 福山秀直, 高橋英彦, 村井俊哉
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌にて発表予定
• [Presentation] 統合失調症患者における白質統合性の低下と灰白質体積および厚さとの相関について (2011)
  • Author(s): 笹本彰彦
  • Organizer: 日本統合失調症学会
  • Place of Presentation: 札幌(確定)
• [Presentation] Abnormal white matter asymmetry in schizophrenia demonstrated by tract-based spatial statistics (2010)
  • Author(s): 宮田淳
  • Organizer: Human Brain Mapping
  • Place of Presentation: バルセロナ、スペイン