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Abnormal connectivity in schizophrenia revealed by multi-modal MRI

Research Project

Project/Area Number 21890119
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

MIYATA Jun  Kyoto University, 大学院・医学研究科, 助教 (90549099)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywords統合失調症 / MRI / 拡散テンソル画像 / connectivity / tract-based spatial statistics / surface-based analysis
Research Abstract

Abnormal connectivity in schizophrenia was investigated by means of the structural MRI and diffusion tensor imaging (DTI). In the analysis of gray matter using structural MRI, the association between cortical thickness and age in healthy people and schizophrenia was revealed. In the DTI analysis for white matter, normal cerebral white matter asymmetry was revealed to be reduced or exaggerated in schizophrenia. This abnormal asymmetry was also revealed to be the neural correlate of certain symptoms of schizophrenia.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] Age-related cortical thinning in schizophrenia.2011

    • Author(s)
      Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
    • Journal Title

      Schizophrenia research 125

      Pages: 21-29

    • NAID

      120002723136

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related cortical thinning in schizophrenia2011

    • Author(s)
      Manabu Kubota
    • Journal Title

      Schizophrenia Research

      Volume: 125 Pages: 21-29

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging.

    • Author(s)
      Miyata T, Sasamoto A, Koelkebeck K, Hirao K, Ueda K, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
    • Journal Title

      Hum Brain Mapp in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Asymmetry of White Matter Integrity in Schizophrenia Revealed by Voxelwise Diffusion Tensor Imaging

    • Author(s)
      Jun Miyata
    • Journal Title

      Human Brain Mapping

      Volume: (In press)(未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 統合失調症患者における白質統合性の低下と灰白質体積および厚さとの相関について2011

    • Author(s)
      笹本彰彦, 宮田淳, 久保田学, 川田良作, 藤本心祐, 田中祐輔, 澤本仲克, 福山秀直, 高橋英彦, 村井俊哉
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌にて発表予定
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症患者における白質統合性の低下と灰白質体積および厚さとの相関について2011

    • Author(s)
      笹本彰彦
    • Organizer
      日本統合失調症学会
    • Place of Presentation
      札幌(確定)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Abnormal white matter asymmetry in schizophrenia demonstrated by tract-based spatial statistics2010

    • Author(s)
      宮田淳
    • Organizer
      Human Brain Mapping
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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