| Project/Area Number |
21890154
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUMOTO Tomoya Hiroshima University, 大学院・医歯薬学総合研究科, 研究員 (30552567)
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| Research Collaborator |
YAMAWAKI Shigeto 広島大学, 大学院・医歯薬学合研究科, 教授 (40230601)
MORINOBU Shigeru 広島大学, 大学院・医歯薬学合研究科, 准教授 (30191042)
KOJIMA Masami 産業技術総合研究所, セルエンジニアリング研究部門, グループ長 (40344171)
TAKAHASHI Masami 北里大学, 医学部, 教授 (10318826)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | うつ病 / BDNF / pro-domain |
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| Research Abstract |
Brain-derived neurotrophic factor (BDNF) is a secreted protein that plays a key role in brain function, while the function of pro-domain BDNF was unknown. In this study, pro-domain BDNF was detected in brain neurons for the first time. It might exist as a complex with BDNF. The role of pro-domain BDNF in depression is being examined.
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