| Project/Area Number |
21890261
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
MAEDA Kazuhiro Jikei University School of Medicine, 医学部, 助教 (50548849)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,535,000 (Direct Cost: ¥1,950,000、Indirect Cost: ¥585,000)
Fiscal Year 2010: ¥1,196,000 (Direct Cost: ¥920,000、Indirect Cost: ¥276,000)
Fiscal Year 2009: ¥1,339,000 (Direct Cost: ¥1,030,000、Indirect Cost: ¥309,000)
|
|---|
| Keywords | 破骨細胞 / Wnt / Wntシグナル / 骨吸収 / 関節リウマチ |
|---|
| Research Abstract |
We have previously reported that noncanonical Wnt signaling enhanced osteoclastogenesis. To clarify the role of noncanonical Wnt signaling in osteoclastogenesis, we generated osteoclast precursor-specific Ror2, one of the noncanonical Wnt receptor,-deficient mice. These mice exhibited impaired osteoclastogenesis due to suppression of RANK expression in osteoclast precursors, indicating that noncanonical Wnt signaling enhances osteoclastogenesis through RANK expression.
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