To clarify the molecular mechanism of novel therapeutic agent which suppresses bone resorption through inhibits noncanonical Wnt signaling.

• Project/Area Number: 21890261
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Jikei University School of Medicine
• Principal Investigator: MAEDA Kazuhiro Jikei University School of Medicine, 医学部, 助教 (50548849)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,535,000 (Direct Cost: ¥1,950,000、Indirect Cost: ¥585,000); Fiscal Year 2010: ¥1,196,000 (Direct Cost: ¥920,000、Indirect Cost: ¥276,000); Fiscal Year 2009: ¥1,339,000 (Direct Cost: ¥1,030,000、Indirect Cost: ¥309,000)
• Keywords: 破骨細胞 / Wnt / Wntシグナル / 骨吸収 / 関節リウマチ

Research Abstract

We have previously reported that noncanonical Wnt signaling enhanced osteoclastogenesis. To clarify the role of noncanonical Wnt signaling in osteoclastogenesis, we generated osteoclast precursor-specific Ror2, one of the noncanonical Wnt receptor,-deficient mice. These mice exhibited impaired osteoclastogenesis due to suppression of RANK expression in osteoclast precursors, indicating that noncanonical Wnt signaling enhances osteoclastogenesis through RANK expression.

Research Products

• [Journal Article] Regulatory Mechanism of Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Wnt Signals. (2011)
  • Author(s): N.Takahashi, K.Maeda, A.Ishihara, S.Uehara, Y.Kobayashi
  • Journal Title: Front Biosci. 16 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Regulatory Mechanism of Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Wnt Signals. (2011)
  • Author(s): Naoyuki Takahashi, et al.
  • Journal Title: Front Biosci Volume: 16 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Regulatory Mechanism of Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Wnt Signals (2010)
  • Author(s): Naoyuki Takahashi, Kazuhiro Maeda, Akihiro Ishihara, Shunsuke Uehara, Yasuhiro Kobayashi
  • Journal Title: FRONTIERS IN BIOSCIENCE (in press)
  • Peer Reviewed
• [Journal Article] Vocabulary『Wnt5a』 (2009)
  • Author(s): 前田和洋
  • Journal Title: 整形外科 60 Pages: 1100-1100
• [Journal Article] Vocabulary 『Wnt5a』 (2009)
  • Author(s): 前田和洋
  • Journal Title: 整形外科 60 Pages: 1100-1100
• [Presentation] Wnt5aによる破骨細胞の分化促進効果 (2010)
  • Author(s): 小林泰浩、前田和洋、上原俊介、高田伊知郎、加藤茂明、丸毛啓史、宇田川信之、高橋直之
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions. (2010)
  • Author(s): Y.Kobayashi, K.Maeda, A.Ishihara, S.Uehara, Takada, S.Kato, M.Nishita, Y.Minami, K.Marumo, N.Udagawa, N.Takahashi
  • Organizer: 第3回国際骨免疫学会議
  • Place of Presentation: Santorini, Greece
  • Year and Date: 2010-06-22
• [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions (2010)
  • Author(s): Yasuhiro Kobayashi
  • Organizer: 第3回国際骨免疫学会議
  • Place of Presentation: Santorini, Greece
  • Year and Date: 2010-06-22
• [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions. (2009)
  • Author(s): Y.Kobayashi, K.Maeda, A.Ishihara, I.Takada, S.Kato, M.Nishita, Y.Minami, K.Marumo, N.Udagawa, N.Takahashi
  • Organizer: The 26^<th> Naito conference on osteobiology
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2009-11-04
• [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions (2009)
  • Author(s): Y.Kobayashi, K.Maeda, et al
  • Organizer: The 26^<th> Naito conference on osteobiology
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2009-11-04