| Project/Area Number |
21890275
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Asahi University |
|---|
Principal Investigator |
INOMATA Megumi Asahi University, 歯学部, 助教 (40553798)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
|---|
| Keywords | 歯周病原細菌 / Porphyromonas gingivalis / LPS / 歯周組織由来細胞 / 血管内皮細胞 / LL-37 / 歯周病 / オートファジー / 歯肉線維芽細胞 |
|---|
| Research Abstract |
Recently, it has been reported that proinflammatory responses of host cells to periodontopathic bacteria Porphyromonas gingivalis (Pg) affect not only periodontal functions but also general health. This study therefore investigated the responses of host cells to Pg. Intriguingly, dead Pg cells, but not live cells, had cell-stimulating activity. In addition, Pg components, including LPS, lipid A, and fimbriae also activated cell responses. These results suggested that live Pg cells can evade from host recognition and invade into host cells to conceal themselves. Furthermore, live Pg cells killed by several in-host factors may activate proinflammatory responses of host cells.
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